Tacrolimus impurity 69 CAS CATO-C4X-130069
| CAS No. | CATO-C4X-130069 |
| Molecular Formula | C44H71NO13 |
| Molecular Weight | 822.03 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, Tacrolimus impurity 69 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 822.03 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Tacrolimus impurity 69 (CAS CATO-C4X-130069, C44H71NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tacrolimus impurity 69 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C44H71NO13 |
| Molecular Weight | 822.03 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Tacrolimus Standards
- Tacrolimus Hydroxy Acid Impurity (CAS 1700657-83-5)
- Tacrolimus 21-Carboxy Acid (CAS CATO-C4X-130029)
- Tacrolimus impurity 65 (CAS CATO-C4X-130065)
- Tacrolimus impurity 70 (CAS CATO-C4X-130070)
- Tacrolimus impurity 66 (CAS CATO-C4X-130066)
- Tacrolimus impurity 62 (CAS CATO-C4X-130062)
- Tacrolimus Methyl Ether (CAS 124554-16-1)
- Tacrolimus Impurity 39 (CAS CATO-C4X-130039)
Recommended Standards
- Oxacyclohexane Open Ring Tacrolimus (CAS 144432-23-5)
- N-Desthiobiotin-N-bis(PEG4-t-butyl ester) (CAS 2353409-60-4)
- Tulathromycin A Impurity 8 (CAS 2051579-09-8)
- 4,4,8,8,12,12-Hexa-p-tolyl-8,12-dihydro-4H-benzo[1,9]quinolizino[3,4,5,6,7-defg]acridine (CAS 1131007-94-7)
- Erlotinib impurity 137 (CAS 1318599-96-0)
- Revefenacin Impurity 26 (CAS 108015-71-0)
- Amiodarone Impurity 32 (CAS 134-92-9)
- 2-Bromo-5-chloro-4-methoxypyridine (CAS 1211520-39-6)
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- 1-Bromo-4-hexylbenzene (CAS 23703-22-2)
- N-Desmethyl Doxycycline (CAS 86271-83-2)
- 4-Amino-6-fluorocinnoline-3-carboxamide (CAS 161373-29-1)
- Insulin Degludec Impurity 27 (CAS CATO-C4X-215727)
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