Retigabine Impurity 1 CAS CATO-C4X-13141
| CAS No. | CATO-C4X-13141 |
| Molecular Formula | C16H18FN3O2 |
| Molecular Weight | 303.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Retigabine Impurity 1.
As a process- or degradation-related impurity, Retigabine Impurity 1 (CAS CATO-C4X-13141, C16H18FN3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Retigabine Impurity 1 (C16H18FN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Retigabine Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H18FN3O2 |
| Molecular Weight | 303.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Retigabine Standards
- Retigabine (CAS 150812-12-7)
- Retigabine impurity 8 (CAS CATO-C4X-13148)
- Retigabine impurity 9 (CAS CATO-C4X-13149)
- Retigabine impurity 12 (CAS CATO-C4X-13152)
- Retigabine impurity 10 (CAS CATO-C4X-13150)
- Retigabine impurity 13 (CAS CATO-C4X-13153)
- Retigabine Genotoxic Impurity 1 (CAS 491871-67-1)
- Retigabine Impurity 2 (CAS CATO-C4X-13142)
Recommended Standards
- Faropenem Impurity 70 (CAS CATO-C4X-128970)
- Faropenem Impurity 67 (CAS CATO-C4X-128967)
- Faropenem Impurity 63 (CAS CATO-C4X-128963)
- Safinamide Impurity 2 (CAS 1160513-60-9)
- Urapidil Impurity 2 (CAS CATO-C4X-19242)
- Luliconazole impurity 29 (CAS CATO-C4X-285329)
- Tezacaftor Impurity C28 (CAS 1294504-68-9)
- ethyl 2-amino-3-(4-chlorophenyl)-3-hydroxypropanoate hydrochloride (CAS 2031259-14-8)
- 5-Chloro-3-iodo-1-methyl-1H-pyrrolo[2,3-c]pyridine (CAS 2231673-21-3)
- 1H-1,2,3-Triazol-1-amine (CAS 584-14-5)
- (2-Bromo-3-methylphenyl)(1H-imidazol-1-yl)methanone (CAS 1383784-60-8)
- 2-[(2-Chlorophenyl)methanesulfonyl]-N-methyl-N-phenylacetamide (CAS 339110-03-1)
- Methyl (E)-2-(1-(4-chlorophenyl)ethylidene)hydrazine-1-carboxylate (CAS 95855-11-1)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com