Retigabine impurity 12 CAS CATO-C4X-13152
| CAS No. | CATO-C4X-13152 |
| Molecular Formula | C16H18FN3O2 |
| Molecular Weight | 303.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 303.33 g/mol gives Retigabine impurity 12 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Retigabine impurity 12 (CAS CATO-C4X-13152), a pharmacopoeial impurity reference standard (molecular formula C16H18FN3O2, MW 303.33 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Retigabine impurity 12 (C16H18FN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Retigabine impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18FN3O2 |
| Molecular Weight | 303.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Retigabine Standards
- Retigabine (CAS 150812-12-7)
- Retigabine Impurity 1 (CAS CATO-C4X-13141)
- Retigabine impurity 8 (CAS CATO-C4X-13148)
- Retigabine impurity 9 (CAS CATO-C4X-13149)
- Retigabine impurity 10 (CAS CATO-C4X-13150)
- Retigabine impurity 13 (CAS CATO-C4X-13153)
- Retigabine Genotoxic Impurity 1 (CAS 491871-67-1)
- Retigabine Impurity 2 (CAS CATO-C4X-13142)
Recommended Standards
- Safinamide Impurity 2 (CAS 1160513-60-9)
- Epalrestat Impurity 3 (CAS 794510-29-5)
- Dotinurad Impurity 50 (CAS CATO-C4X-249450)
- Phenmedipham D3 (CAS 1773497-41-8)
- Dapagliflozin Impurity 201 (CAS CATO-C4X-1138201)
- Palonosetron Impurity 44 (CAS CATO-C4X-110544)
- Tedizolid Impurity 97 (CAS 885951-58-6)
- 7-Methyl-1-(2-(o-tolyloxy)ethyl)indoline-2,3-dione (CAS 620932-10-7)
- Faropenem Impurity 11 Disodium Salt (CAS 130609-10-8)
- N-Isopropylcycloheptanamine hydrochloride (CAS 1609404-03-6)
- (1E,4E)-terephthalaldehyde dioxime (CAS 18705-39-0)
- Hexahydro-1H-pyrrolo[1,2-a]azepin-5(6H)-one (CAS 111633-56-8)
- 4-(3-Fluoroazetidin-1-yl)piperidine (CAS 1147422-28-3)
- (D-Ala1)-Peptide T amide (CAS 106362-34-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com