Retigabine impurity 9 CAS CATO-C4X-13149
| CAS No. | CATO-C4X-13149 |
| Molecular Formula | C16H18FN3O2 |
| Molecular Weight | 303.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Retigabine impurity 9.
CATO supplies Retigabine impurity 9 (CAS CATO-C4X-13149), a pharmacopoeial impurity reference standard (molecular formula C16H18FN3O2, MW 303.33 g/mol) used for the identification and quantification of trace impurities in APIs.
Retigabine impurity 9 (C16H18FN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H18FN3O2 |
| Molecular Weight | 303.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Retigabine Standards
- Retigabine (CAS 150812-12-7)
- Retigabine Impurity 1 (CAS CATO-C4X-13141)
- Retigabine impurity 8 (CAS CATO-C4X-13148)
- Retigabine impurity 12 (CAS CATO-C4X-13152)
- Retigabine impurity 10 (CAS CATO-C4X-13150)
- Retigabine impurity 13 (CAS CATO-C4X-13153)
- Retigabine Genotoxic Impurity 1 (CAS 491871-67-1)
- Retigabine Impurity 2 (CAS CATO-C4X-13142)
Recommended Standards
- Safinamide Impurity 2 (CAS 1160513-60-9)
- Epalrestat Impurity 3 (CAS 794510-29-5)
- Faropenem Impurity 70 (CAS CATO-C4X-128970)
- Dotinurad Impurity 50 (CAS CATO-C4X-249450)
- Biapenem impurity 32 (CAS CATO-C4X-227332)
- Ipratropium Bromide EP Impurity B (CAS 58073-59-9)
- Methotrexate EP Impurity A (CAS 945-24-4)
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- 5-[(5-iodofuran-2-yl)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 126965-20-6)
- Methyl 3-chloro-5-(methylsulfonyl)benzoate (CAS 151104-62-0)
- Anti-TF Antigen Peptide P30-1 trifluoroacetate salt (CAS 573664-50-3)
Why CATO?
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