Retigabine impurity 13 CAS CATO-C4X-13153
| CAS No. | CATO-C4X-13153 |
| Molecular Formula | C16H16FN3O4 |
| Molecular Weight | 333.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Retigabine impurity 13 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Retigabine impurity 13 (CAS CATO-C4X-13153, C16H16FN3O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Retigabine impurity 13 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 333.31 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C16H16FN3O4 |
| Molecular Weight | 333.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Retigabine Standards
- Retigabine (CAS 150812-12-7)
- Retigabine Impurity 1 (CAS CATO-C4X-13141)
- Retigabine impurity 8 (CAS CATO-C4X-13148)
- Retigabine impurity 9 (CAS CATO-C4X-13149)
- Retigabine impurity 12 (CAS CATO-C4X-13152)
- Retigabine Impurity 2 (CAS CATO-C4X-13142)
- Retigabine Impurity 3 (CAS 1263404-73-4)
- Retigabine impurity 11 (CAS CATO-C4X-13151)
Recommended Standards
- Regorafenib Impurity 23 (CAS CATO-C4X-104723)
- Norfloxacin Impurity 19 (CAS 74011-42-0)
- N-(m-tolyl)-2-(2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)acetamide (CAS 478030-71-6)
- Lomefloxacin Impurity 8 (CAS 195259-12-2)
- Baricitinib Impurity 135 (CAS 2101302-36-5)
- Piperacillin EP Impurity F (CAS 3112735-85-7)
- Nintedanib Impurity 186 (CAS CATO-C4X-1814186)
- Ethyl 4-methyl-2-((6-methylpyridin-3-yl)oxy)thiazole-5-carboxylate (CAS 1199215-94-5)
- Methyl 4-(2-aminoacetamido)benzoate hydrochloride (CAS 1209619-38-4)
- Niclosamide Monohydrate (CAS 73360-56-2)
- Formamidine- (CAS 1215714-80-9)
- N-Hydroxy-6-methyl-3,4-dihydroisoquinoline-2(1H)-carboximidamide (CAS 782389-50-8)
- 1-(Tributylstannyl)-1H-imidazole (CAS 27605-35-2)
- Cycloaspeptide A (CAS 109171-13-3)
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