Sunitinib Impurity 60 CAS CATO-C4X-133360
| CAS No. | CATO-C4X-133360 |
| Molecular Formula | C12H13FN2 |
| Molecular Weight | 204.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Sunitinib Impurity 60 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Sunitinib Impurity 60 (CAS CATO-C4X-133360) is a certified pharmaceutical impurity reference standard with the molecular formula C12H13FN2 and a molecular weight of 204.24 g/mol.
The molecular framework of Sunitinib Impurity 60 (C12H13FN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sunitinib Impurity 60 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H13FN2 |
| Molecular Weight | 204.24 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Sunitinib Standards
- Sunitinib Impurity 39 (CAS CATO-C4X-133339)
- Sunitinib Impurity 10 (CAS 477575-12-5)
- Sunitinib Impurity 52 (CAS 2199-59-9)
- Sunitinib Impurity 12 (CAS CATO-C4X-133312)
- Sunitinib Impurity 14 (CAS 1309935-08-7)
- Sunitinib Impurity 1 (CAS 37746-78-4)
- Sunitinib Impurity 43 (CAS 14352-65-9)
- Sunitinib Impurity 13 (CAS 1309935-09-8)
Recommended Standards
- Vonoprazan Impurity 65 (CAS 1610043-62-3)
- Carbaryl D3 (CAS 1433961-56-8)
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