Beclometasone dipropionate EP Impurity A CAS 69224-79-9
| CAS No. | 69224-79-9 |
| Molecular Formula | C25H33ClO6 |
| Molecular Weight | 464.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Beclometasone dipropionate EP Impurity A (C25H33ClO6) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Beclometasone dipropionate EP Impurity A (CAS 69224-79-9) is a certified pharmaceutical impurity reference standard with the molecular formula C25H33ClO6 and a molecular weight of 464.98 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H33ClO6 |
| Molecular Weight | 464.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
Related Beclometasone Standards
- Beclometasone dipropionate EP Impurity H (CAS 5534-18-9)
- Beclometasone Impurity 27 (CAS CATO-C4X-147427)
- Beclometasone Impurity 48 (CAS CATO-C4X-147448)
- Beclometasone Dipropionate Monohydrate EP Impurity I (CAS 52092-12-3)
- Beclometasone Impurity 38 (CAS CATO-C4X-147438)
- Beclometasone Impurity 53 (CAS CATO-C4X-147453)
- Beclometasone Dipropionate Monohydrate EP Impurity Q (CAS CATO-C4X-147417)
- Beclometasone Impurity 44 (CAS 18769-20-5)
Recommended Standards
- Alclometasone Dipropionate Impurity 4 (CAS 76576-24-4)
- 9,9'-(5-Chloro-1,3-phenylene)diphenanthrene (CAS 1369431-34-4)
- N-(4-Chlorophenethyl)-3-((4-methoxy-N-methylphenyl)sulfonamido)thiophene-2-carboxamide (CAS 1116017-47-0)
- Alclometasone Dipropionate Impurity 5 (CAS 129459-98-9)
- Sivelestat Impurity 30 (CAS CATO-C4X-212330)
- Firocoxib Impurity 3 (CAS CATO-C4X-32113)
- Testosterone Impurity N10 (CAS 26614-48-2)
- 2-(Chloromethyl)-3-isopropyl-3H-imidazo[4,5-b]pyridine (CAS 1443285-67-3)
- (S)-N-((1-Methylpyrrolidin-2-yl)methyl)cyclopropanamine (CAS 1429058-50-3)
- 4-Bromo-1-fluoro-2-(isopentyloxy)benzene (CAS 1595040-76-8)
- 2,2,3,3,4,4,5,5-Octafluoropentyl difluoromethylether (CAS 742063-29-2)
- 5-Butyl-1,3-diphenyl-1H-pyrazole (CAS 16492-64-1)
- 4,5,6,7-tetrafluoro-2-({[3-(trifluoromethyl)phenyl]thio}methyl)benzo[b]furan (CAS 256525-96-9)
- Semaglutide Impurity 142 (CAS CATO-C4X-2226142)
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