Metoclopramide impurity 64 CAS CATO-C4X-141564
| CAS No. | CATO-C4X-141564 |
| Molecular Formula | C11H12ClNO4 |
| Molecular Weight | 257.67 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Metoclopramide impurity 64 is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Metoclopramide impurity 64 (CAS CATO-C4X-141564, C11H12ClNO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Metoclopramide impurity 64 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 257.67 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H12ClNO4 |
| Molecular Weight | 257.67 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Metoclopramide Standards
- Metoclopramide Impurity 17 (CAS CATO-C4X-141517)
- Metoclopramide EP Impurity B (CAS 4093-31-6)
- Metoclopramide Impurity 24 (CAS CATO-C4X-141524)
- Metoclopramide (CAS CATO-C4X-141557)
- Metoclopramide impurity 82 (CAS CATO-C4X-141582)
- Metoclopramide impurity 70 (CAS 102313-35-9)
- Metoclopramide Impurity 125 (CAS 476615-04-0)
- Metoclopramide Impurity 121 (CAS CATO-C4X-1415121)
Recommended Standards
- Deferasirox Impurity 17 (CAS 155528-92-0)
- 2-Chloro-4-phenylpyrido[2,3-b]pyrazin-3(4H)-one (CAS 1334103-17-1)
- 4-Chloro-6-(4-methylpiperazin-1-yl)-5-nitropyrimidine (CAS 154418-73-2)
- etoclopramide Impurity 13 (CAS CATO-C4X-141513)
- Epichlorohydrin Impurity 9 (CAS 6452-58-0)
- Atorvastatin Impurity N1 (CAS 148127-12-2)
- Erdafitinib Impurity 2 (CAS 123342-12-1)
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- Diethyl (Trimethylsilyl) Phosphite (CAS 13716-45-5)
- 2-Ethyl-N-[2-(4-isopropylphenoxy)ethyl]-6-methylaniline (CAS 1040684-07-8)
- 6'-fluoro-1',2'-dihydrospiro[cyclopropane-1,3'-indole] (CAS 1461713-29-0)
- Racemethorphan hydrobromide (CAS 6031-86-3)
- Cyclolinopeptide B (CAS 193139-41-2)
- Smac-N7 Peptide (CAS 401913-57-3)
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