Loratadine Impurity 45 CAS CATO-C4X-142645
| CAS No. | CATO-C4X-142645 |
| Molecular Formula | C25H29ClN4O2 |
| Molecular Weight | 452.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 452.98 g/mol gives Loratadine Impurity 45 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Loratadine Impurity 45 (CAS CATO-C4X-142645, C25H29ClN4O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C25H29ClN4O2, Loratadine Impurity 45 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 452.98 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H29ClN4O2 |
| Molecular Weight | 452.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Loratadine Standards
- Loratadine Impurity 59 (CAS CATO-C4X-142659)
- Loratadine Impurity 57 (CAS CATO-C4X-142657)
- Loratadine Impurity 47 (CAS CATO-C4X-142647)
- Loratadine Impurity 25 (CAS CATO-C4X-142625)
- Loratadine Impurity 82 (CAS CATO-C4X-142682)
- Loratadine Impurity 100 (CAS CATO-C4X-1426100)
- Loratadine Impurity 41 (CAS CATO-C4X-142641)
- Loratadine Impurity 63 (CAS CATO-C4X-142663)
Recommended Standards
- 4-Chloro-N-((4-ethyl-5-((3-methoxybenzyl)thio)-4H-1,2,4-triazol-3-yl)methyl)benzenesulfonamide (CAS 338421-93-5)
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- Mavacamten Impurity 3 (CAS CATO-C4X-29823)
- Arbidol Impurity 7 HCl (CAS CATO-C4X-11297)
- Rufinamide Impurity 7 (CAS CATO-C4X-23397)
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- N-(3-Nitrophenyl)-2-{[4-({[(3-nitrophenyl)carbamoyl]methyl}sulfanyl)butyl]sulfanyl}acetamide (CAS 301194-27-4)
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- tert-Butyl ((3S,4R)-4-fluoropyrrolidin-3-yl)carbamate (CAS 1033718-89-6)
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- (2S,4S)-1-(2-Bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile (CAS 426844-30-6)
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