Loratadine Impurity 51 CAS CATO-C4X-142651
| CAS No. | CATO-C4X-142651 |
| Molecular Formula | C27H35ClN4O3 |
| Molecular Weight | 499.04 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Loratadine Impurity 51 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Loratadine Impurity 51 (CAS CATO-C4X-142651, C27H35ClN4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Loratadine Impurity 51 (C27H35ClN4O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Loratadine Impurity 51 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C27H35ClN4O3 |
| Molecular Weight | 499.04 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Loratadine Standards
- Loratadine Impurity 49 (CAS CATO-C4X-142649)
- Loratadine Impurity 56 (CAS CATO-C4X-142656)
- Loratadine Impurity 54 (CAS CATO-C4X-142654)
- Loratadine Impurity 44 (CAS CATO-C4X-142644)
- Loratadine Impurity 42 (CAS CATO-C4X-142642)
- Loratadine Impurity 48 (CAS CATO-C4X-142648)
- Loratadine Impurity 46 (CAS CATO-C4X-142646)
- Loratadine Impurity 60 (CAS CATO-C4X-142660)
Recommended Standards
- (S)-gne-140 (CAS 2003234-64-6)
- (2-chloro-4-phenoxyphenyl)-(4-(((3R,6S)-6-(hydroxymethyl)oxan-3-yl)amino)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)methanone (CAS 2095393-15-8)
- (R)-GNE-140 (CAS 2003234-63-5)
- Ixazomib Impurity 72 (CAS CATO-C4X-126772)
- Cimetidine EP Impurity G (CAS 31857-31-5)
- Binimetinib Impurity 6 (CAS CATO-C4X-30506)
- Pregabalin impurity 91 (CAS 159029-27-3)
- Telmisartan Impurity 42 (CAS 1860008-29-2)
- 2-(((2,4-Dimethoxyphenyl)amino)methyl)-6-methoxyphenol (CAS 1019526-32-9)
- 7-Chloro-1,4-dihydrocyclopenta[b]indol-3(2H)-one (CAS 441067-87-4)
- 4-Bromo-2-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1150561-79-7)
- 1-Propyl-1H-indazole-3-carbaldehyde (CAS 944556-39-2)
- 4-(Furan-2-carbonyl)-5-methyl-2-phenyl-1H-pyrazol-3(2H)-one (CAS 89076-04-0)
- (Tyr?)-C-Peptide (dog) (CAS 101135-67-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com