Desloratadine Impurity 64 CAS CATO-C4X-143064
| CAS No. | CATO-C4X-143064 |
| Molecular Formula | C19H18ClN3O2 |
| Molecular Weight | 355.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Desloratadine Impurity 64 is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Desloratadine Impurity 64 (CAS CATO-C4X-143064) is a certified pharmaceutical impurity reference standard with the molecular formula C19H18ClN3O2 and a molecular weight of 355.82 g/mol.
Desloratadine Impurity 64 (C19H18ClN3O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Desloratadine Impurity 64 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18ClN3O2 |
| Molecular Weight | 355.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Desloratadine Standards
- Desloratadine Impurity 65 (CAS CATO-C4X-143065)
- Desloratadine Related Compound A (CAS 117796-50-6)
- Desloratadine impurity 66 (CAS CATO-C4X-143066)
- Desloratadine Impurity 28 (CAS CATO-C4X-143028)
- Desloratadine Impurity 9 (CAS 117796-52-8)
- Desloratadine Impurity 63 (CAS CATO-C4X-143063)
- Desloratadine Impurity 29 (CAS 79779-58-1)
- Iso Desloratadine Hydrochloride (CAS 432543-89-0)
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