Clozapine Impurity 15 CAS 156632-03-0
| CAS No. | 156632-03-0 |
| Molecular Formula | C18H18ClN5O |
| Molecular Weight | 355.82 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Clozapine Impurity 15.
CATO supplies Clozapine Impurity 15 (CAS 156632-03-0), a pharmacopoeial impurity reference standard (molecular formula C18H18ClN5O, MW 355.82 g/mol) used for the identification and quantification of trace impurities in APIs.
Clozapine Impurity 15 (C18H18ClN5O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Clozapine Impurity 15 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18ClN5O |
| Molecular Weight | 355.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2001 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Clozapine Standards
- Clozapine EP Impuirty C-D8 N-nitroso (CAS CATO-C4X-134018)
- Clozapine EP Impurity D (CAS 65514-71-8)
- Clozapine N-Oxide (CAS 34233-69-7)
- Clozapine Impurity 14 (CAS 1025951-76-1)
- Clozapine Impurity 22 (CAS CATO-C4X-134022)
- Clozapine-d8 (CAS 1185053-50-2)
- Clozapine-D4 (CAS 204395-52-8)
- Clozapine-D3 (CAS 1215691-72-7)
Recommended Standards
- Plafibride - API Standards (CAS 63394-05-8)
- Desloratadine Impurity 64 (CAS CATO-C4X-143064)
- N'-(3-chloro-1H-indole-2-carbonyl)thiophene-2-sulfonohydrazide (CAS 866051-17-4)
- Desloratadine Impurity 65 (CAS CATO-C4X-143065)
- Atrasentan Impurity 109 (CAS 1059052-17-3)
- Pranoprofen Impurity 46 (CAS CATO-C4X-181146)
- Levocarnitine Impurity 15 (CAS 931426-07-2)
- 3-((5-Methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)-N-phenylbenzamide (CAS 919280-40-3)
- 1-(3-Chloropropoxy)-4-nitrobenzene (CAS 79096-54-1)
- 2-(4-Amino-pyrazol-1-yl)-N-cyclopentyl-acetamide hydrochloride (CAS 1361112-11-9)
- 4-(3-Fluoro-4-methoxyphenyl)-2-hydrazinylpyrimidine (CAS 1410821-09-8)
- 2-Chloro-4-methylbenzoic Acid (CAS 7697-25-8)
- (3-chlorophenyl)methylhydrazine;hydrochloride (CAS 260057-49-6)
- Peptide 74 (H-8545.0500) (CAS 132116-39-3)
Why CATO?
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