Halometasone Impurity 5 CAS CATO-C4X-14465
| CAS No. | CATO-C4X-14465 |
| Molecular Formula | C22H25ClF2O6 |
| Molecular Weight | 458.88 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Halometasone Impurity 5.
As a process- or degradation-related impurity, Halometasone Impurity 5 (CAS CATO-C4X-14465, C22H25ClF2O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Halometasone Impurity 5 (C22H25ClF2O6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Halometasone Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H25ClF2O6 |
| Molecular Weight | 458.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Halometasone Standards
- Halometasone impurity 10 (CAS CATO-C4X-144610)
- Halometasone impurity 13 (CAS CATO-C4X-144613)
- Halometasone impurity 12 (CAS CATO-C4X-144612)
- Halometasone Impurity 8 (CAS 28895-70-7)
- Halometasone (CAS 50629-82-8)
- Halometasone Impurity 6 (CAS CATO-C4X-14466)
- Halometasone impurity 15 (CAS CATO-C4X-144615)
- Halometasone impurity 17 (CAS 35540-75-1)
Recommended Standards
- 36530-06-0 12-Chloro-2,11,13,22,30,31-hexaaza-12-boraoctacyclo[21.6.1.1~10,14~.0~3,11~.0~4,9~.0~13,21~.0~15,20~.0~24,29~]hentriaconta-1(29),3,5,7,9,14,16,18,20,23,25,27-dodecaene (non-preferred name) DTXSID20746554 (CAS 36530-06-0)
- (S)-2-Amino-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide (CAS 1466563-97-2)
- 4-(4-(4-Chlorophenyl)thiazol-2-yl)-N-(3-(trifluoromethyl)phenyl)benzamide (CAS 338408-10-9)
- 2-((4-Allyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-chloro-3-(trifluoromethyl)phenyl)acetamide (CAS 618879-84-8)
- Betaquiline Impurity 24 (CAS CATO-C4X-116724)
- Tolvaptan impurity 113 (CAS CATO-C4X-1955113)
- Ceftazidime Impurity 16 (CAS 86299-47-0)
- H-N-Me-Glu(OMe)-OH.HCl (CAS 2044711-08-0)
- Thiocyanic acidpiperidine (CAS 22205-64-7)
- 4-(3-Bromo-2-fluorobenzyl)morpholine, 97% (CAS 1355247-75-4)
- (9BS,14S,15aS)-14-(tert-butyl)-4,5,9b,12,13,14,15,15a-octahydro-10H-benzo[6,7]cyclohepta[1,2,3-de]pyrido[2,1-a]isoquinolin-14-ol (CAS 56245-67-1)
- N-Ethyl-2,5-dimethyl-N-phenylbenzenesulfonamide (CAS 26004-48-8)
- Methyl thiomorpholine-2-carboxylate (CAS 852706-09-3)
- Heptapeptide-6 (CAS CATO-CPTD788823)
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