Indometacin EP Impurity D CAS CATO-C4X-147012
| CAS No. | CATO-C4X-147012 |
| Molecular Formula | C19H16ClNO4 |
| Molecular Weight | 357.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Indometacin EP Impurity D (CAS CATO-C4X-147012), a pharmacopoeial impurity reference standard (molecular formula C19H16ClNO4, MW 357.79 g/mol) used for the identification and quantification of trace impurities in APIs.
Indometacin EP Impurity D (C19H16ClNO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C19H16ClNO4 |
| Molecular Weight | 357.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Indometacin Standards
- Indometacin EP Impurity E (CAS 807614-94-4)
- Indometacin Impurity 47 (CAS CATO-C4X-147047)
- Indometacin Impurity 54 (CAS CATO-C4X-147054)
- Indometacin Impurity 65 (CAS CATO-C4X-147065)
- Indometacin EP Impurity H (CAS 1601-18-9)
- Indometacin EP Impurity I (CAS 16401-99-3)
- Indometacin Impurity 55 (CAS CATO-C4X-147055)
- Indometacin EP Impurity G (CAS 402849-26-7)
Recommended Standards
- CAS 2241757-94-6 (CAS 2241757-94-6)
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- Ethyl 5-(2-chlorobenzamido)-3-methylbenzofuran-2-carboxylate (CAS 923178-80-7)
- Imrecoxib Impurity 73 (CAS CATO-C4X-237973)
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- Tirofiban Impurity 71 (CAS CATO-C4X-125471)
- 3,3'-Diethoxy-[1,1'-biphenyl]-4,4'-dicarboxylicacid (CAS 2051918-30-8)
- 5-Methoxy-N,N-dimethyl-1H-indole-3-propanamine (CAS 709028-93-3)
- Benzyl(2s,5s)-2,5-dimethylmorpholine-4-carboxylate (CAS 1821813-41-5)
- 5-Bromo-4-nitro-1H-indazole-3-carboxylic acid (CAS 865886-79-9)
- 2-Chloro-1-(2,6-dichloro-3-fluorophenyl)ethan-1-one (CAS 1249849-11-3)
- N-(2-Bromo-3-fluorobenzyl)-N-ethylpropan-1-amine (CAS 1505107-50-5)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
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