Indometacin Impurity 43 CAS CATO-C4X-147043
| CAS No. | CATO-C4X-147043 |
| Molecular Formula | C23H20ClNO9 |
| Molecular Weight | 489.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Indometacin Impurity 43.
Indometacin Impurity 43 (CAS CATO-C4X-147043) is a certified pharmaceutical impurity reference standard with the molecular formula C23H20ClNO9 and a molecular weight of 489.86 g/mol.
Based on its molecular formula C23H20ClNO9, Indometacin Impurity 43 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 489.86 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H20ClNO9 |
| Molecular Weight | 489.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Indometacin Standards
- Indometacin Impurity 28 (CAS 193603-94-0)
- Indometacin Impurity 37 (CAS CATO-C4X-147037)
- Indometacin Impurity 38 (CAS CATO-C4X-147038)
- Indometacin Impurity 42 (CAS CATO-C4X-147042)
- Indometacin Impurity 41 (CAS CATO-C4X-147041)
- Indometacin Impurity 44 (CAS CATO-C4X-147044)
- Indometacin Impurity 56 (CAS CATO-C4X-147056)
- Indometacin Impurity 21 (CAS 71848-87-8)
Recommended Standards
- 5-[(4-Chlorophenyl)sulfanyl]-4-{[(2,6-dichlorophenyl)methoxy]methyl}-1-methyl-3-phenyl-1H-pyrazole (CAS 321538-27-6)
- 2-{2-[(4-methoxyphenyl)formamido]acetamido}ethyl 3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylate (CAS 338419-61-7)
- NESS 0327 (CAS 494844-07-4)
- 1-((4-Chlorophenyl)sulfonyl)-N'-(3-(trifluoromethyl)benzoyl)piperidine-4-carbohydrazide (CAS 477872-86-9)
- Valsartan Impurity 61 (CAS 137862-57-8)
- Lidocaine Impurity 68 (CAS CATO-C4X-167968)
- Posaconazole impurity 225 (CAS CATO-C4X-1208225)
- Bempedoic Acid Impurity N4 (CAS 119703-02-5)
- 2-Methyl-N-(3-methylcyclopentyl)cyclohexan-1-amine (CAS 1343223-11-9)
- 4-(Methylthio)benzofuran (CAS 173306-92-8)
- 3-Fluoro-benzene-1,2-diamine dihydrochloride (CAS 1414959-15-1)
- 3-((4-(Dimethylamino)benzylidene)amino)quinazolin-4(3H)-one (CAS 88404-51-7)
- 4-Methoxy-6-(2-nitro-1-propen-1-yl)-1,3-benzodioxole (CAS 17055-07-1)
- Semaglutide Impurity 176 (CAS CATO-C4X-2226176)
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