Indometacin Impurity 44 CAS CATO-C4X-147044
| CAS No. | CATO-C4X-147044 |
| Molecular Formula | C25H28ClNO10 |
| Molecular Weight | 537.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Indometacin Impurity 44 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Indometacin Impurity 44 (CAS CATO-C4X-147044) is a certified pharmaceutical impurity reference standard with the molecular formula C25H28ClNO10 and a molecular weight of 537.94 g/mol.
Indometacin Impurity 44 (C25H28ClNO10) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Indometacin Impurity 44 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C25H28ClNO10 |
| Molecular Weight | 537.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Indometacin Standards
- Indometacin Impurity 41 (CAS CATO-C4X-147041)
- Indometacin Impurity 42 (CAS CATO-C4X-147042)
- Indometacin Farnesil (CAS 85801-02-1)
- Indometacin Impurity 28 (CAS 193603-94-0)
- Indometacin Impurity 37 (CAS CATO-C4X-147037)
- Indometacin Impurity 38 (CAS CATO-C4X-147038)
- Indometacin Impurity 43 (CAS CATO-C4X-147043)
- Indometacin EP Impurity J (CAS 402849-25-6)
Recommended Standards
- Gadolinium(III) iodide (CAS 13572-98-0)
- Methyl 2-[2-({4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}sulfonyl)-4,5-dimethoxyphenyl]acetate (CAS 1024415-60-8)
- (4-(2-(4-((Tert-butyldiphenylsilyl)oxy)piperidin-1-yl)ethoxy)-3-chlorophenyl)boronic acid (CAS 1704074-62-3)
- C16-Ceramide (CAS 24696-26-2)
- Telmisartan Impurity 15 (CAS 1026438-56-1)
- Netupitant Impurity 41 (CAS CATO-C4X-122341)
- Fluvastatin Impurity 15 Sodium Salt (CAS CATO-C4X-165115)
- 6-Nitro-2-phenylpyrazolo[1,5-a]pyrimidine (CAS 88796-46-7)
- 5-(4-Bromophenyl)-1,2,3-trifluorobenzene (CAS 178820-38-7)
- Ethyl (E)-pent-3-enoate (CAS 3724-66-1)
- 1-[(2,6-Dichlorophenyl)methyl]-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (CAS 303988-08-1)
- 1,2-Di([1,1':4',1''-terphenyl]-4-yl)ethanone (CAS 105599-05-1)
- 3-(5-Methyl-2-nitrophenoxy)propan-1-amine (CAS 848640-46-0)
- Tau Peptide (295-309) trifluoroacetate salt (CAS 330456-46-7)
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