Indometacin Impurity 60 CAS CATO-C4X-147060
| CAS No. | CATO-C4X-147060 |
| Molecular Formula | C7H8N3O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Indometacin Impurity 60 (CAS CATO-C4X-147060, C7H8N3O5SNa) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Indometacin Impurity 60 (C7H8N3O5SNa) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.5, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 269.21 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8N3O5S Na |
| Molecular Weight | 269.21 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Indometacin Standards
- Indometacin Impurity 17 (CAS 10414-67-2)
- Indometacin EP Impurity H (CAS 1601-18-9)
- Indometacin EP Impurity I (CAS 16401-99-3)
- Indometacin Impurity 28 (CAS 193603-94-0)
- Indometacin EP Impurity B (CAS 2882-15-7)
- Indometacin Impurity 57 (CAS 3050535-92-4)
- Indometacin EP Impurity C (CAS 4018-82-0)
- Indometacin EP Impurity J (CAS 402849-25-6)
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