Ketoconazole impurity 34 CAS CATO-C4X-147234
| CAS No. | CATO-C4X-147234 |
| Molecular Formula | C18H15BrCl2O4 |
| Molecular Weight | 446.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 446.12 g/mol gives Ketoconazole impurity 34 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Ketoconazole impurity 34 (CAS CATO-C4X-147234), a pharmacopoeial impurity reference standard (molecular formula C18H15BrCl2O4, MW 446.12 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Ketoconazole impurity 34 (C18H15BrCl2O4) contains a flavonoid core, a hydroxyl group, an ether linkage, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 446.12 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Ketoconazole impurity 34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H15BrCl2O4 |
| Molecular Weight | 446.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
Related Ketoconazole Standards
- Ketoconazole Impurity 36 (CAS CATO-C4X-147236)
- Ketoconazole Impurity 6 (CAS 61397-56-6)
- Ketoconazole Impurity 9 (CAS 331949-30-5)
- Ketoconazole Impurity 10 (CAS 70894-66-5)
- Ketoconazole impurity 30 (CAS CATO-C4X-147230)
- Ketoconazole EP Impurity E (CAS 134071-44-6)
- Ketoconazole Impurity 14 (CAS 170210-50-1)
- Ketoconazole impurity 32 (CAS CATO-C4X-147232)
Recommended Standards
- trans-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate (CAS 61397-57-7)
- 1H-Indole-2,3-dione, 5-chloro-1-[(3,4-dichlorophenyl)methyl]-, 3-[O-(3-chloro-1-oxopropyl)oxime] (CAS 320420-75-5)
- 1H,1H,2H-Perfluoro-1-decene (CAS 21652-58-4)
- Brimonidine Impurity 33 (CAS CATO-C4X-156633)
- Ceftazidime EP Impurity B (CAS 97148-38-4)
- Venetoclax Impurity 55 (CAS 2514648-06-5)
- Ketorolac Impurity 21 (CAS CATO-C4X-166921)
- 1-Amino-3-(3,4-dimethyl-phenoxy)-propan-2-ol (CAS 50738-96-0)
- Ticagrelor impurity 162 HCl (CAS 1643378-54-4)
- (2,4-Dimethoxyphenyl)(ethyl)sulfane (CAS 861080-89-9)
- 2-(2-Chloro-6-ethoxyquinolin-3-yl)acetonitrile (CAS 1017329-78-0)
- 3-Iodo-1-(propan-2-yl)-1H-pyrazole-4-carboxylic acid (CAS 1946823-02-4)
- 2-Amino-2-(benzo[d][1,3]dioxol-5-yl)acetic acid (CAS 39533-43-2)
- Peptide Impurity 06 (CAS CATO-CPTD788806)
Why CATO?
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