Ketoconazole Impurity 36 CAS CATO-C4X-147236
| CAS No. | CATO-C4X-147236 |
| Molecular Formula | C18H15BrCl2O4 |
| Molecular Weight | 446.12 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Ketoconazole Impurity 36 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Ketoconazole Impurity 36 (CAS CATO-C4X-147236, C18H15BrCl2O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Ketoconazole Impurity 36 (C18H15BrCl2O4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, chlorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H15BrCl2O4 |
| Molecular Weight | 446.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl/Br-containing |
Related Ketoconazole Standards
- Ketoconazole impurity 34 (CAS CATO-C4X-147234)
- Ketoconazole Impurity 6 (CAS 61397-56-6)
- Ketoconazole Impurity 9 (CAS 331949-30-5)
- Ketoconazole Impurity 10 (CAS 70894-66-5)
- Ketoconazole impurity 30 (CAS CATO-C4X-147230)
- Ketoconazole EP Impurity E (CAS 134071-44-6)
- Ketoconazole Impurity 14 (CAS 170210-50-1)
- Ketoconazole impurity 32 (CAS CATO-C4X-147232)
Recommended Standards
- trans-[2-Bromomethyl-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl]methyl Benzoate (CAS 61397-57-7)
- 1H-Indole-2,3-dione, 5-chloro-1-[(3,4-dichlorophenyl)methyl]-, 3-[O-(3-chloro-1-oxopropyl)oxime] (CAS 320420-75-5)
- Perfluoro(4-methyl-3,6-dioxaoct-7-ene)sulfonyl Fluoride (CAS 16090-14-5)
- 1H,1H,2H-Perfluoro-1-decene (CAS 21652-58-4)
- Mupirocin Impurity 23 (CAS CATO-C4X-170623)
- Bromhexine EP Impurity C (CAS 57365-08-9)
- Etoricoxib Impurity 88 (CAS CATO-C4X-108088)
- 1H-Purine-6-carbonyl chloride (CAS 70265-75-7)
- 2-(4-Fluoro-3-(pentyloxy)phenyl)ethanol (CAS 1443343-53-0)
- 4-(4-Methoxybenzyloxy)-2-fluorobenzonitrile (CAS 1242152-56-2)
- Acetaldehyde O-(2-phenylpyrimidin-4-yl) oxime (CAS 89967-09-9)
- 6,6-Difluorobicyclo[3.2.0]Heptan-2-One (CAS 161941-21-5)
- (7-Amino-3,4-dihydroisoquinolin-2(1h)-yl)(phenyl)methanone (CAS 855644-25-6)
- Osteoblast-Adhesive Peptide (CAS 193613-75-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com