Midazolam EP Impurity E Maleate Salt CAS CATO-C4X-150922
| CAS No. | CATO-C4X-150922 |
| Molecular Formula | C16H15ClFN3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Midazolam EP Impurity E Maleate Salt (CAS CATO-C4X-150922) is a certified pharmaceutical impurity reference standard with the molecular formula C16H15ClFN3C4H4O4 and a molecular weight of 419.84 g/mol.
The molecular framework of Midazolam EP Impurity E Maleate Salt (C16H15ClFN3C4H4O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H15ClFN3 C4H4O4 |
| Molecular Weight | 419.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam N-β-D-Glucuronide (~90%, contains ~10% inorganic salts) (CAS 1033824-50-8)
- Midazolam EP Impurity I (CAS 112811-67-3)
- Midazolam EP Impurity H (CAS 119401-13-7)
- Midazolam 2,5-Dioxide-d6 (CAS 1215321-98-4)
- MidazolaM-d6 (CAS 1246819-79-3)
- Midazolam Impurity 20 (CAS 151921-06-1)
- Midazolam Impurity 14 (CAS 2531288-23-8)
- Midazolam EP Impurity F (CAS 2886-65-9)
Recommended Standards
- Cefixime Impurity 19 (CAS CATO-C4X-113919)
- Lacosamide Impurity 46 (CAS 1253790-25-8)
- Avermectin impurity 4 (CAS CATO-C4X-15524)
- 3-Nitro-4'-(pyrrolidin-1-ylsulfonyl)-[1,1'-biphenyl]-4-ol (CAS 1261946-90-0)
- Ethyl (2E)-2-(2,4-difluorobenzenesulfonyl)-3-[(3,4-dimethoxyphenyl)amino]prop-2-enoate (CAS 1327176-76-0)
- 1-(Aminomethyl)-1-methylcyclopropane Hydrochloride (CAS 1260779-19-8)
- 4-Fluoro-N-isopropylbenzo[d]isoxazol-3-amine (CAS 1344688-32-9)
- Methyl 2-ethynyl-4-methylbenzoate (CAS 2113642-19-4)
- 1-(2-(4-Nitrophenoxy)ethyl)pyrrolidine (CAS 265654-77-1)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
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