Midazolam Impurity 40 CAS CATO-C4X-150940
| CAS No. | CATO-C4X-150940 |
| Molecular Formula | C18H17ClFN3 |
| Molecular Weight | 329.80 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Midazolam Impurity 40 (CAS CATO-C4X-150940), a pharmacopoeial impurity reference standard (molecular formula C18H17ClFN3, MW 329.80 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C18H17ClFN3, Midazolam Impurity 40 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 329.80 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Midazolam Impurity 40 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H17ClFN3 |
| Molecular Weight | 329.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Midazolam Standards
- Midazolam EP Impurity J (CAS 59469-08-8)
- Midazolam-d5 (Major) Discontinued See M343003 (CAS 395067-42-2)
- Midazolam EP Impurity A (CAS 59468-07-4)
- Midazolam Impurity 28 (CAS CATO-C4X-150928)
- 【禁售不询】Midazolam (CAS 59467-70-8)
- Midazolam EP Impurity B (CAS 59469-74-8)
- Midazolam Impurity 25 (CAS CATO-C4X-150925)
- Midazolam Impurity 1 (CAS 59468-90-5)
Recommended Standards
- 2-[2-(4-chlorophenyl)-4-phenyl-1,3-thiazol-5-yl]ethanoate 2-[2-(4-chlorophenyl)-4-phenyl-5-thiazolyl]acetate 23821-72-9 A816923 (CAS 23821-72-9)
- N'-[(1Z)-(4-Chlorophenyl)methylidene]-3-(1H-pyrrol-1-yl)thiophene-2-carbohydrazide (CAS 478062-83-8)
- Tert-butyl (R)-(8-chloro-4-oxo-2,3,4,5-tetrahydropyrido[4,3-b][1,4]thiazepin-3-yl)carbamate (CAS CATO-CIM-100317)
- N-(4-chlorophenyl)-4-methyl-2-(pyridin-4-yl)thiazole-5-carboxamide (CAS 321430-18-6)
- Stiripentol impurity 3 (CAS 144850-45-3)
- Tirofiban Impurity 6 (CAS CATO-C4X-12546)
- Paliperidone Impurity 80 (CAS 130049-87-5)
- tert-Butyl 3-hydroxy-3-(pyridin-2-yl)azetidine-1-carboxylate (CAS 1415560-24-5)
- Butyl(phenyl)sulfane (CAS 1126-80-3)
- 3-Chloro-4-(1h-pyrazol-1-yl)benzonitrile (CAS 1340265-32-8)
- Methyl 5-bromo-2,3-dihydro-1h-indole-6-carboxylate (CAS 1788041-64-4)
- 2,3-difluoro-5-nitro-pyridine (CAS 954219-68-2)
- 4-Bromo-5-methylisothiazol-3(2H)-one (CAS 25629-53-2)
- Semaglutide impurity 96 (CAS CATO-C4X-222696)
Why CATO?
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com