Rebamipide Impurity 35 HCl CAS CATO-C4X-152335
| CAS No. | CATO-C4X-152335 |
| Molecular Formula | C19H14Cl2N2O4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Rebamipide Impurity 35 HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Rebamipide Impurity 35 HCl (CAS CATO-C4X-152335, C19H14Cl2N2O4HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Rebamipide Impurity 35 HCl (C19H14Cl2N2O4HCl) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C19H14Cl2N2O4 HCl |
| Molecular Weight | 441.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Rebamipide Standards
- Rebamipide Impurity 4 (CAS 100342-53-8)
- Rebamipide impurity 25 (CAS 1022283-52-8)
- Rebamipide Impurity 43 (CAS 1028268-32-7)
- Rebamipide impurity 20 (CAS 1205-74-9)
- Rebamipide-d4 (CAS 1219409-06-9)
- Rebamipide Impurity 12 (CAS 132210-24-3)
- Rebamipide Impurity 60 (CAS 135252-30-1)
- Rebamipide impurity 02 (CAS 1984832-92-9)
Recommended Standards
- Vildagliptin Impurity 54 (CAS 16104-28-2)
- Vildagliptin Impurity 23 (CAS CATO-C4X-110023)
- Atorvastatin Impurity 144 (CAS CATO-C4X-1132144)
- Benzo[d]oxazol-2-yl(2-chloro-6-fluorophenyl)methyl dimethylcarbamate (CAS 104029-82-5)
- [{2-[(2-Cyclohex-1-en-1-ylethyl)amino]-2-oxoethyl}(phenyl)amino]acetic acid (CAS 1142204-89-4)
- Cyclopropyl(4-ethylphenyl)methanone (CAS 50664-71-6)
- 1-(3,4,5-Trimethoxyphenyl)-1H-pyrrole-2,5-dione (CAS 883033-64-5)
- Ibrutinib Impurity 51 (CAS CATO-C4X-106451)
- 2-Methyl-6-(trifluoromethyl)imidazo[2,1-b]thiazole-5-carboxylic acid (CAS 1369332-25-1)
- Tirzepatide Impurity 12 (CAS CATO-C4X-324012)
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