Thioctic acid Impurity 14 CAS CATO-C4X-152614

Description

The occurrence of Thioctic acid Impurity 14 is closely related to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

As a process- or degradation-related impurity, Thioctic acid Impurity 14 (CAS CATO-C4X-152614, C16H30O4S4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Thioctic acid Impurity 14 (C16H30O4S4) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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