Brimonidine Impurity 28 CAS CATO-C4X-156628
| CAS No. | CATO-C4X-156628 |
| Molecular Formula | C12H11BrN6O |
| Molecular Weight | 335.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Brimonidine Impurity 28 (C12H11BrN6O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Brimonidine Impurity 28 (CAS CATO-C4X-156628) is a certified pharmaceutical impurity reference standard with the molecular formula C12H11BrN6O and a molecular weight of 335.16 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11BrN6O |
| Molecular Weight | 335.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
Related Brimonidine Standards
- Brimonidine Impurity 43 (CAS CATO-C4X-156643)
- Brimonidine Impurity N3 (CAS 1158184-23-6)
- Brimonidine Impurity 17 (CAS 134892-47-0)
- Brimonidine-2,3-dione (CAS 182627-95-8)
- Brimonidine Impurity 30 (CAS CATO-C4X-156630)
- Brimonidine Impurity 36 (CAS CATO-C4X-156636)
- Brimonidine Impurity 35 (CAS CATO-C4X-156635)
- Brimonidine Impurity 44 (CAS CATO-C4X-156644)
Recommended Standards
- Ethyl 5-amino-1-(4-bromophenyl)-4-cyanopyrazole-3-carboxylate (CAS 96723-27-2)
- 8-Bromo-3,7-dihydro-3-methyl-7-(phenylmethyl)-1H-purine-2,6-dione (CAS 93703-26-5)
- Diethyl (4-bromo-2,5-dimethylbenzyl)phosphonate (CAS 1170667-43-2)
- 6-(2,4-Dichlorophenyl)-3-(difluoromethyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (CAS 832739-43-2)
- Chlortetracycline Hydrochloride EP Impurity L (CAS CATO-C4X-233022)
- Naltrexone impurity 35 (CAS CATO-C4X-147535)
- Sorafenib Impurity 60 (CAS CATO-C4X-112460)
- n-(Piperidin-3-ylmethyl)furan-2-carboxamide (CAS 1251343-39-1)
- Ciprofloxacin impurity 47 (CAS 93106-58-2（free base）)
- Ethyl 2,5-dichloro-3-methylbenzoate (CAS 1806346-80-4)
- (2R)-2-[(4S,5R)-4,5-Dihydro-4,5-diphenyl-2-oxazolyl]-1-(diphenylphosphino)piperidine (CAS 2757084-61-8)
- Methyl 7-azabicyclo[2.2.1]Heptane-1-carboxylate hydrochloride (CAS 518046-34-9)
- Ethyl 2-(2,5-dimethyl-1H-pyrrol-1-yl)acetate (CAS 5044-21-3)
- Semaglutide impurity 89 (CAS CATO-C4X-222689)
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