Brimonidine Impurity 44 CAS CATO-C4X-156644
| CAS No. | CATO-C4X-156644 |
| Molecular Formula | C11H8BrN7O2 |
| Molecular Weight | 350.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Brimonidine Impurity 44.
Brimonidine Impurity 44 (CAS CATO-C4X-156644) is a certified pharmaceutical impurity reference standard with the molecular formula C11H8BrN7O2 and a molecular weight of 350.13 g/mol.
The molecular framework of Brimonidine Impurity 44 (C11H8BrN7O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8BrN7O2 |
| Molecular Weight | 350.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 7 |
Related Brimonidine Standards
- Brimonidine Impurity 35 (CAS CATO-C4X-156635)
- Brimonidine Impurity 29 (CAS CATO-C4X-156629)
- Brimonidine Impurity 28 (CAS CATO-C4X-156628)
- Brimonidine Impurity 43 (CAS CATO-C4X-156643)
- Brimonidine Impurity N3 (CAS 1158184-23-6)
- Brimonidine Impurity 17 (CAS 134892-47-0)
- Brimonidine-2,3-dione (CAS 182627-95-8)
- Brimonidine Impurity 30 (CAS CATO-C4X-156630)
Recommended Standards
- Crisaborole Impurity 37 (CAS CATO-C4X-202137)
- 5-Methyl-3-(perfluoropentyl)-1H-pyrazole (CAS 82633-43-0)
- 1-(4-Bromo-2-fluorophenyl)-5-(1h-pyrrol-1-yl)-1h-pyrazole-4-carboxylic acid (CAS 1224155-10-5)
- N-(5-fluoro-4-formyl-3-iodopyridin-2-yl)pivalamide (CAS 1299607-38-7)
- Levosimendan Impurity 46 (CAS CATO-C4X-130846)
- Relebactam Impurity 4 (CAS CATO-C4X-21444)
- Dyclonine impurity 35 (CAS 2052-13-3)
- n-((5-Methylisoxazol-3-yl)methyl)-4-(trifluoromethyl)aniline (CAS 1275068-12-6)
- Methyl 7-methoxy-4-oxo-1,4-dihydroquinoline-2-carboxylate (CAS 77474-23-8)
- 1-(2-Oxopropyl)quinolin-4(1H)-one (CAS 31678-21-4)
- 2-(5,7,8,9-Tetrahydro-5-hydroxy-6H-benzocyclohepten-6-ylidene)acetic acid (CAS 520505-01-5)
- (4R)-4-((3S,7S,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-(sulfooxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate (CAS 89232-83-7)
- 4,8-Dibromo-2-phenylquinoline (CAS 1189106-08-8)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
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