Cetirizine Impurity 32 CAS CATO-C4X-158232
| CAS No. | CATO-C4X-158232 |
| Molecular Formula | C24H31ClN2O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cetirizine Impurity 32.
As a process- or degradation-related impurity, Cetirizine Impurity 32 (CAS CATO-C4X-158232, C24H31ClN2O5HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Cetirizine Impurity 32 (C24H31ClN2O5HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 499.43 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H31ClN2O5 2*HCl |
| Molecular Weight | 499.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Cetirizine Standards
- Cetirizine EP Impurity B (CAS 1000690-91-4)
- Cetirizine Impurity 10 (CAS 1016-78-0)
- rac Cetirizine N-Oxide (Mixture of Diastereomers) (CAS 1076199-80-8)
- Cetirizine USP Related Compound B (CAS 108983-83-1)
- Cetirizine EP Impurity G (CAS 109806-71-5)
- (R)-Cetirizine-d4 Dihydrochloride (CAS 1133210-23-7)
- Cetirizine Impurity N19 (CAS 113740-61-7)
- rac Cetirizine-d8 N-Oxide (CAS 1216444-13-1)
Recommended Standards
- Amisulpride Impurity 28 (CAS 80036-86-8)
- Cabozantinib Impurity 41 (CAS 2105956-20-3)
- N-Nitroso Piperacillin impurity 101 (CAS CATO-C4X-1732101)
- Apixaban Impurity 188 (CAS CATO-C4X-1088188)
- 1-(6-(Difluoromethoxy)pyridin-3-yl)ethan-1-one (CAS 1198166-10-7)
- 1-Methyl-4-(2-phenoxyethanesulfonyl)benzene (CAS 28611-88-3)
- N-Methyl-2-(quinoxalin-2-ylsulfanyl)acetamide (CAS 338394-75-5)
- Rosuvastatin Impurity 55 (CAS 289042-10-0)
- 1-(Pyridin-2-yl)pent-4-yn-1-ol (CAS 1342577-93-8)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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