Clobetasol Propionate Impurity 23 CAS CATO-C4X-159223
| CAS No. | CATO-C4X-159223 |
| Molecular Formula | C22H29FO3 |
| Molecular Weight | 360.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Clobetasol Propionate Impurity 23 (CAS CATO-C4X-159223, C22H29FO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clobetasol Propionate Impurity 23 (C22H29FO3) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 360.46 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29FO3 |
| Molecular Weight | 360.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Clobetasol Standards
- Clobetasol Propionate Related Compound 1 (CAS 61618-89-1)
- Clobetasol Propionate EP Impurity F (CAS 2412496-00-3)
- Clobetasol Propionate Impurity 12 (CAS 3109-01-1)
- Clobetasol Propionate EP Impurity B (CAS 1356190-17-4)
- Clobetasol Propionate EP Impurity G (CAS 25122-41-2)
- Clobetasol Propionate Impurity 20 (CAS CATO-C4X-159220)
- Clobetasol-d5 (CAS CATO-CCAD303553)
- Clobetasol Propionate EP Impurity H (CAS 4351-48-8)
Recommended Standards
- Nizatidine impurity 17 (CAS CATO-C4X-138017)
- Pioglitazone-d4 (CAS 1134163-29-3)
- N2-Nitroso Nizatidine (CAS CATO-C4X-138015)
- N-(Diethoxymethyl)-3-[3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophen-2-yl]-1H-pyrazol-5-amine (CAS 1025724-92-8)
- Cefixime Impurity 81 (CAS CATO-C4X-113981)
- Elagolix Impurity 58 (CAS CATO-C4X-206858)
- Vitamin Impurity 33 (CAS 6381-77-7)
- 8-Methyl-2-phenylquinoline-4-carbonyl chloride (CAS 854863-92-6)
- Silodosin impurity N1 (CAS 1338365-54-0)
- ({[1,1'-Biphenyl]-4-yl}methyl)(2-methylpropyl)amine (CAS 893574-80-6)
- (2-Methylquinolin-7-yl)boronic acid (CAS 947304-73-6)
- 1-(3-Hydroxypropyl)-3-methyl-1H-pyrazol-5(4H)-one (CAS 342615-75-2)
- 3,3,3-Trifluoro-2-(3-fluorophenyl)propan-1-amine (CAS 1531521-68-2)
- Des-Ile27-Tirzepatide (CAS CATO-CPTD788946)
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