Clobetasol Propionate EP Impurity F CAS 2412496-00-3
| CAS No. | 2412496-00-3 |
| Molecular Formula | C22H27FO4 |
| Molecular Weight | 374.45 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Clobetasol Propionate EP Impurity F (C22H27FO4) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 374.45 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Clobetasol Propionate EP Impurity F (CAS 2412496-00-3), a pharmacopoeial impurity reference standard (molecular formula C22H27FO4, MW 374.45 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Clobetasol Propionate EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H27FO4 |
| Molecular Weight | 374.45 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2000 |
| Halogen Content | F-containing |
Related Clobetasol Standards
- Clobetasol Propionate Related Compound 1 (CAS 61618-89-1)
- Clobetasol Propionate Impurity 23 (CAS CATO-C4X-159223)
- Clobetasol Propionate EP Impurity B (CAS 1356190-17-4)
- Clobetasol Propionate EP Impurity G (CAS 25122-41-2)
- Clobetasol Propionate Impurity 20 (CAS CATO-C4X-159220)
- Clobetasol-d5 (CAS CATO-CCAD303553)
- Clobetasol Propionate Impurity 12 (CAS 3109-01-1)
- Clobetasol Propionate EP Impurity H (CAS 4351-48-8)
Recommended Standards
- Betamethasone Enol Aldehyde E Isomer (CAS 52647-07-1)
- Cilastatin EP Impurity A(Mixture Of Diastereomers) (CAS CATO-C4X-19601)
- Betamethasone Enol Aldehyde Z Isomer (CAS 52647-06-0)
- Cilastatin Impurity 38 (CAS CATO-C4X-196038)
- Amlodipine Impurity 36 (CAS 331258-36-7)
- Olanzapine EP Impurity D (Olanzapine USP Related Compound C, Olanzapine N-Oxide (Piperazine N1-Oxide)) (CAS 174794-02-6)
- Finerenone Impurity 213 (CAS CATO-C4X-2880213)
- N-(5-Butylpyrazolo[1,5-a]pyrimidin-7-yl)-2-(trifluoromethyl)benzamide (CAS 174858-58-3)
- 1,3-Dichloro-2-methylpropane (CAS 616-19-3)
- 1-[1-(dimethoxymethyl)vinyl]pyrrolidine (CAS 76282-55-8)
- (2-Chloro-5-(cyclopentylcarbamoyl)phenyl)boronic acid (CAS 1449135-57-2)
- KSHN00402RI (CAS 30953-87-8)
- 1,1,2,2-Tetrafluoropropane (CAS 40723-63-5)
- Peptide 46 (H-4054.0500) (CAS 192122-40-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com