Dasatinib impurity 63 CAS CATO-C4X-160763
| CAS No. | CATO-C4X-160763 |
| Molecular Formula | C21H23Cl2N7O2S |
| Molecular Weight | 508.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dasatinib impurity 63 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Dasatinib impurity 63 (CAS CATO-C4X-160763, C21H23Cl2N7O2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Dasatinib impurity 63 (C21H23Cl2N7O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C21H23Cl2N7O2S |
| Molecular Weight | 508.42 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Related Dasatinib Standards
- Dasatinib-d8 N-Oxide (CAS 1189988-36-0)
- Dasatinib Impurity 12 (CAS 910297-57-3)
- Dasatinib Impurity 15 (CAS 910297-58-4)
- Dasatinib Impurity 2 (CAS 910297-52-8)
- Dasatinib Impurity 47 (CAS CATO-C4X-160747)
- Dasatinib Impurity 69 (CAS CATO-C4X-160769)
- Dasatinib Impurity 4 (CAS 910297-53-9)
- Dasatinib Impurity 48 (CAS CATO-C4X-160748)
Recommended Standards
- Crizotinib Impurity 72 (CAS CATO-C4X-102572)
- 126485-47-0 ACMC-20dj70 Benzoic acid,4-hydroxy-3,5-dimethoxy-,(2,3,4,4a,6,10b-hexahydro-3,4,8,10-tetrahydroxy-9-methoxy-6-oxopyrano[3,2-c][2]benzopyran-2-yl)methylester, [2R-(2a,3b,4a,4aa,10bb)]- (9CI) (CAS 126485-47-0)
- Bicalutamide Impurity 35 (CAS CATO-C4X-101335)
- 5,5'-(9-Oxo-9H-fluorene-2,7-diyl)diisophthalic acid (CAS 1588979-47-8)
- Dextromethorphan Impurity 31 (CAS 23974-90-5)
- (Z/E)-Ceftizoxime Impurity 50 (CAS 770660-21-4)
- Suvorexant Impurity 33 (CAS 1030377-32-2)
- (S)-1,4-dioxa-7-azaspiro[4.5]decane-8-carboxylic acid (CAS 1234692-61-5)
- 1-(2,4-Difluorophenyl)-4,4,4-trifluorobutane-1,3-dione (CAS 64287-18-9)
- N-ethyl-2-(2-oxopyrrolidin-1-yl)acetamide (CAS 7457-96-7)
- (but-3-yn-1-yl)(2-methoxyethyl)amine (CAS 1248404-06-9)
- 2-fluoro-3-hydroxy-5-methylcyclohex-2-en-1-one (CAS 2231677-08-8)
- 4-Formylpiperazine-1-carboximidamide sulfate (CAS 77723-10-5)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
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