Dolutegravir Impurity 46 CAS 2244245-34-7
| CAS No. | 2244245-34-7 |
| Molecular Formula | C21H23N3O5 |
| Molecular Weight | 397.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Dolutegravir Impurity 46 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Dolutegravir Impurity 46 (CAS 2244245-34-7), a pharmacopoeial impurity reference standard (molecular formula C21H23N3O5, MW 397.42 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Dolutegravir Impurity 46 (C21H23N3O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C21H23N3O5 |
| Molecular Weight | 397.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 50 (CAS CATO-C4X-162050)
- Dolutegravir Impurity 28 (CAS 1646862-09-0)
- Dolutegravir Impurity 8 (CAS 1863916-88-4)
- Dolutegravir Impurity 9 (CAS 1863916-87-3)
- Dolutegravir Impurity 23 (CAS CATO-C4X-162023)
- Dolutegravir Impurity 31 (CAS CATO-C4X-162031)
- Dolutegravir Impurity 48 (CAS CATO-C4X-162048)
- Dolutegravir Impurity 53 (CAS CATO-C4X-162053)
Recommended Standards
- 2-(((1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl)amino)ethane-1-sulfonic acid (CAS 497258-54-5)
- Fmoc-D-Cit-OH (CAS 200344-33-8)
- Finerenone Impurity 39 (CAS CATO-C4X-288039)
- Fmoc-CIT-OH (CAS 133174-15-9)
- Palbociclib Impurity 87 HCl (CAS 2174002-29-8(free base))
- Riluzole Impurity 7 (CAS 1456696-94-8)
- Isavuconazole Impurity 29 (CAS CATO-C4X-123629)
- 2-Amino-2-(3-(trifluoromethyl)phenyl)propanoic acid (CAS 1134679-10-9)
- 2-(3,5-Dimethyl-1h-pyrazol-1-yl)-N-(2,2,2-trifluoroethyl)acetamide (CAS 1223017-37-5)
- 2-Amino-7-bromo-4,6-dichloro-8-fluoroquinoline-3-carbonitrile (CAS 2025359-86-6)
- 2,2,2-Trifluoroethyl (2-chloro-6-(trifluoromethyl)phenyl)carbamate (CAS 1087798-25-1)
- 6-Deoxypenciclovir hydrochloride (CAS 246021-75-0)
- 2-Bromo-4-isopropylbenzaldehyde (CAS 861897-63-4)
- Peptide Impurity 34 (CAS 21282-09-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com