Dolutegravir Impurity 52 CAS CATO-C4X-162052
| CAS No. | CATO-C4X-162052 |
| Molecular Formula | C20H18F2N3NaO5 |
| Molecular Weight | 441.36 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 441.36 g/mol gives Dolutegravir Impurity 52 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Dolutegravir Impurity 52 (CAS CATO-C4X-162052) is a certified pharmaceutical impurity reference standard with the molecular formula C20H18F2N3NaO5 and a molecular weight of 441.36 g/mol.
Based on its molecular formula C20H18F2N3NaO5, Dolutegravir Impurity 52 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 441.36 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H18F2N3NaO5 |
| Molecular Weight | 441.36 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 55 (CAS CATO-C4X-162055)
- Dolutegravir M3 (CAS 1485692-24-7)
- Dolutegravir Impurity 61 (CAS CATO-C4X-162061)
- Dolutegravir Impurity 21 (CAS CATO-C4X-162021)
- Dolutegravir Impurity 15 (CAS 2384108-28-3)
- Dolutegravir Impurity 34 (CAS 2227442-13-7)
- Dolutegravir Impurity 35 (CAS 2583719-57-5)
- Dolutegravir Impurity 42 (CAS CATO-C4X-162042)
Recommended Standards
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- Amorolfine Impurity N2 (CAS 67468-13-7)
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- 1-(Pyridin-2-yl)hex-5-en-2-one (CAS 202808-92-2)
- 6-Nitrobenzo[c]isoxazole (CAS 15264-44-5)
- tert-Butyl 2-(4-bromophenoxy)acetate (CAS 282116-88-5)
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