Dolutegravir Impurity 68 CAS CATO-C4X-162068
| CAS No. | CATO-C4X-162068 |
| Molecular Formula | C20H20F2N3O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Dolutegravir Impurity 68 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Dolutegravir Impurity 68 (CAS CATO-C4X-162068, C20H20F2N3O5Na) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C20H20F2N3O5Na, Dolutegravir Impurity 68 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 443.38 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Dolutegravir Impurity 68 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H20F2N3O5 Na |
| Molecular Weight | 443.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Sodium Salt (CAS 1051375-19-9)
- Dolutegravir Impurity 22 (CAS 1206102-11-5)
- Dolutegravir Sodium Monohydrate - API Standards (CAS 1229006-39-6)
- Dolutegravir Impurity N13 (CAS 1246616-73-8)
- Dolutegravir Impurity 14 (CAS 127958-23-0)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 27 (CAS 1335210-31-5)
Recommended Standards
- Favipiravir Impurity 11 (CAS 6863-74-7)
- Calcitriol Impurity 59 (CAS 934338-44-0)
- Fluticasone Impurity 102 (CAS CATO-C4X-1650102)
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- 1-Phenylhexahydro-1H-indazol-3(2H)-one (CAS 6118-98-5)
- 4-Chlorophenyl 6-methyl-2-(p-tolyl)quinoline-4-carboxylate (CAS 355419-82-8)
- (4-Cyanomethyl-benzyl)-carbamic acid tert-butyl ester (CAS 187283-18-7)
- 4-Fluoropyridin-3-amine (CAS 106080-41-5)
- 3-(2-Methylphenyl)prop-2-ynoic acid (CAS 7515-27-7)
- Casein kinase II peptide Substrate (CAS 154444-98-1)
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