Fluticasone Impurity 28 CAS CATO-C4X-165028
| CAS No. | CATO-C4X-165028 |
| Molecular Formula | C27H28ClF3O6S |
| Molecular Weight | 573.02 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Fluticasone Impurity 28 (CAS CATO-C4X-165028), a pharmacopoeial impurity reference standard (molecular formula C27H28ClF3O6S, MW 573.02 g/mol) used for the identification and quantification of trace impurities in APIs.
Fluticasone Impurity 28 (C27H28ClF3O6S) contains a steroid core, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H28ClF3O6S |
| Molecular Weight | 573.02 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related Fluticasone Standards
- Fluticasone Furoate Impurity 5 (CAS CATO-C4X-32545)
- Fluticasone Impurity 37 (CAS 948565-92-2)
- Fluticasone Impurity 94 (CAS CATO-C4X-165094)
- Fluticasone Impurity 55 (CAS CATO-C4X-165055)
- Fluticasone Impurity N7 (CAS 80474-27-7)
- Fluticasone Impurity 103 (CAS CATO-C4X-1650103)
- Fluticasone Furoate EP Impurity G (CAS 785806-96-4)
- Fluticasone Impurity 25 (CAS 1374153-88-4)
Recommended Standards
- Calcitriol Impurity 21 (CAS 115648-67-4)
- Calcipotriol Impurity 24 (CAS 112828-13-4)
- Amlodipine Impurity 104 (CAS CATO-C4X-1095104)
- C18 Ceramide-d7(d18:1-d7/18:0) (CAS 1840942-14-4)
- Docusate Sodium Impurity 1 (CAS 96954-01-7)
- Chlorhexidine EP Impurity O 2HCl (CAS 2508008-02-2 (free base))
- Raltitrexed Impurity 40 (CAS CATO-C4X-138640)
- Vapreotide diacetate (CAS 936560-75-7)
- Cyclo(-Arg-Gly-Asp-D-Phe-Val) (CAS 137813-35-5)
- 8-Bromo-6-methyltetrazolo[1,5-a]pyridine (CAS 1820712-78-4)
- Phenobarbital Impurity 01 (CAS 69125-70-8)
- Benzyl 2,2,2-trifluoroacetate (CAS 351-70-2)
- tert-Butyl 5-azaspiro[2.5]octan-8-ylcarbamate (CAS 1232542-24-3)
- Tetrapeptide-3 (CAS 827306-97-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com