Losartan Impurity 25 CAS CATO-C4X-168325
| CAS No. | CATO-C4X-168325 |
| Molecular Formula | C25H25ClN6O5 |
| Molecular Weight | 524.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Losartan Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Losartan Impurity 25 (CAS CATO-C4X-168325, C25H25ClN6O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Losartan Impurity 25 (C25H25ClN6O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 524.96 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C25H25ClN6O5 |
| Molecular Weight | 524.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Losartan Standards
- Losartan Impurity N1 (CAS 1797134-81-6)
- Losartan Impurity 26 (CAS CATO-C4X-168326)
- Losartan Impurity 48 (CAS CATO-C4X-168348)
- Losartan Impurity 39 (CAS CATO-C4X-168339)
- Losartan EP Impurity F (CAS 1332713-64-0)
- Losartan EP Impurity J (CAS 1006062-27-6)
- Losartan Impurity 40 (CAS CATO-C4X-168340)
- Losartan Impurity 41 (CAS CATO-C4X-168341)
Recommended Standards
- (5R)-2,2,8,8,9,9-Hexamethyl-3,3-diphenyl-5-[3-(trimethylsilyl)-2-propyn-1-yl]-4,7-ddioxa-3,8-disiladecane (CAS 1251537-17-3)
- 4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(4-chlorophenyl)-3-hydroxy-1-(pyridin-3-ylmethyl)-1H-pyrrol-2(5H)-one (CAS 497247-66-2)
- Amlodipine Impurity 58 (CAS 140171-50-2)
- Pemafibrate Impurity 65 (CAS CATO-C4X-290365)
- Sugammadex Impurity Org197339-1 (CAS 2379877-90-2)
- Trifarotene impurity 15 (CAS CATO-C4X-313215)
- Triclabendazole Impurity 4 (CAS 145770-89-4)
- Acetylglycyl-L-leucine (CAS 29852-55-9)
- 2-Cyclohexylethyl 4-methylbenzenesulfonate (CAS 21336-37-8)
- ethyl 3-amino-2-methylbutanoate (CAS 4946-35-4)
- 26791-73-1 298X1N12LS Xanthatin 3,3a,4,7,8,8a-Hexahydro-7-methyl-3-methylene-6-(3-oxo-1-butenyl)-2H-cyclohepta(b)furan-2-one 8-epi-Xanthatin UNII-298X1N12LS (CAS 26791-73-1)
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