Losartan Impurity 48 CAS CATO-C4X-168348
| CAS No. | CATO-C4X-168348 |
| Molecular Formula | C30H36Cl2N4O2 |
| Molecular Weight | 555.54 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C30H36Cl2N4O2, Losartan Impurity 48 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 555.54 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Losartan Impurity 48 (CAS CATO-C4X-168348) is a certified pharmaceutical impurity reference standard with the molecular formula C30H36Cl2N4O2 and a molecular weight of 555.54 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C30H36Cl2N4O2 |
| Molecular Weight | 555.54 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Losartan Standards
- Losartan Impurity 25 (CAS CATO-C4X-168325)
- Losartan N1-Glucuronide (CAS 138584-34-6)
- Losartan N2-Glucuronide (CAS 138584-35-7)
- Losartan Impurity N1 (CAS 1797134-81-6)
- Losartan Impurity 27 (CAS CATO-C4X-168327)
- Losartan Impurity 26 (CAS CATO-C4X-168326)
- Losartan Impurity 39 (CAS CATO-C4X-168339)
- Losartan EP Impurity F (CAS 1332713-64-0)
Recommended Standards
- Sorafenib Impurity 60 (CAS CATO-C4X-112460)
- CO 1686 (CAS 1374640-70-6)
- Platinum(2+), bis[2-(2-pyridinylmethylene)hydrazinecarbothioamide-κN2,κS]-, dichlorid (CAS 218617-12-0)
- 1,3,5-Tris(4-(4H-1,2,4-triazol-4-yl)phenoxy)benzene (CAS 1680199-77-2)
- Paliperidone impurity 133 (CAS CATO-C4X-1724133)
- Sugammadex Impurity 61 (CAS 53784-84-2)
- Daptomycin Impurity 17 (CAS CATO-C4X-137817)
- 5-((2-Aminoethyl)amino)pyrimidine-2,4(1H,3H)-dione (CAS 300804-18-6)
- 2-Methylglutaric Acid (CAS 617-62-9)
- 2-(((1-Hydroxy-2-methylpropan-2-yl)amino)methyl)-4-methylphenol (CAS 1343329-05-4)
- [DAla2] Met-Enkephalin, amide (CAS 61090-95-7)
- 1-Cyclopropyl-2-(4-((2,4-difluorophenyl)sulfonyl)piperazin-1-yl)ethan-1-ol (CAS 1396799-61-3)
- 2-{[(tert-butoxy)carbonyl](cyclopropyl)amino}propanoic acid (CAS 900802-61-1)
- Pancreatic Polypeptide (31-36) Free Acid, human (CAS 192432-73-8)
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