Losartan Impurity 27 CAS CATO-C4X-168327
| CAS No. | CATO-C4X-168327 |
| Molecular Formula | C28H27ClN6O8 |
| Molecular Weight | 611.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Losartan Impurity 27 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Losartan Impurity 27 (CAS CATO-C4X-168327), a pharmacopoeial impurity reference standard (molecular formula C28H27ClN6O8, MW 611.00 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Losartan Impurity 27 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 611.00 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C28H27ClN6O8 |
| Molecular Weight | 611.00 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 6 |
Related Losartan Standards
- Losartan N1-Glucuronide (CAS 138584-34-6)
- Losartan N2-Glucuronide (CAS 138584-35-7)
- Losartan EP Impurity H (CAS 133909-99-6)
- Losartan EP Impurity I (CAS 1006062-28-7)
- Losartan Impurity N13 (CAS 133727-10-3)
- Losartan Impurity 48 (CAS CATO-C4X-168348)
- Losartan Impurity N3 (CAS 133910-00-6)
- Losartan Impurity 25 (CAS CATO-C4X-168325)
Recommended Standards
- 2,2'-(2,5-Bis((2-ethylhexyl)oxy)-1,4-phenylene)dithieno[3,2-b]thiophene (CAS 1914976-66-1)
- Allisartan Isoproxil Impurity 5 (CAS CATO-C4X-32175)
- 3-(Tetradecanoyloxy)propane-1,2-diyl bis(decanoate) (CAS 62833-19-6)
- BQ-123 (CAS 136553-81-6)
- Macitentan Impurity 56 (CAS CATO-C4X-117556)
- Mianserin Impurity 75 (CAS CATO-C4X-136975)
- Etomidate Impurity 43 (CAS CATO-C4X-188443)
- (7AS)-6-aminotetrahydropyrrolo[1,2-c]oxazol-3(1H)-one (CAS 1447603-91-9)
- N-(4-Fluorophenyl)(methylsulfanyl)carbothioamide (CAS 33692-68-1)
- 5-Bromo-6-azaindole-3-carbaldehyde (CAS 1369348-93-5)
- 2-Bromo-2,3,3,3-tetrafluoropropanoic acid (CAS 13859-31-9)
- 2-((3-Allyl-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-2-yl)thio)-N-cyclohexylacetamide (CAS 314260-59-8)
- N-(1-Butyl-2-oxo-1,2,3,4-tetrahydroquinolin-6-yl)-2-methoxyacetamide (CAS 946269-82-5)
- [3,5 Diiodo-Tyr7] Peptide T (CAS 128551-40-6)
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