Olopatadine Impurity 67 CAS CATO-C4X-171867
| CAS No. | CATO-C4X-171867 |
| Molecular Formula | C22H24N2OP |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Olopatadine Impurity 67.
As a process- or degradation-related impurity, Olopatadine Impurity 67 (CAS CATO-C4X-171867, C22H24N2OPBr) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olopatadine Impurity 67 (C22H24N2OPBr) is characterized by a steroid core, an amide group, organophosphorus functionality, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H24N2OP Br |
| Molecular Weight | 443.32 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Olopatadine Standards
- Olopatadine Impurity 44 (CAS 111088-69-8)
- Olopatadine Impurity 43 (CAS 1127893-02-0)
- Olopatadine Methyl Ester HCl (CAS 113805-71-3（free base）)
- Olopatadine Impurity 51 (CAS 113806-01-2)
- Olopatadine Ethyl Ester (HCl) (CAS 113806-03-4)
- Olopatadine (CAS 113806-05-6)
- (E)-Olopatadine (CAS 113806-06-7)
- Olopatadine Impurity N3 (CAS 113835-76-0)
Recommended Standards
- Beclometasone Dipropionate Monohydrate EP Impurity L (CAS 114371-33-4)
- Busulfan Impurity 10 (CAS CATO-C4X-145510)
- Dexlansoprazole Impurity 50 (CAS 87-91-2)
- (7R,7aR,8aS)-7-amino-5-methyl-7,7a,8,8a-tetrahydrocyclopropa[d]pyrazino[2,3-b]azepin-6(5H)-one (CAS 2124264-14-6)
- 5-Phenyl-4,5-dihydroisoxazole-3-carbaldehyde (CAS 109000-39-7)
- Methyl 3-(4-bromothiophen-2-yl)-2-hydroxypropanoate (CAS 1480293-09-1)
- 5-(2-Phenyl-1,3-thiazol-5-yl)-1,2-oxazole (CAS 338414-59-8)
- (E)-1-(3-((2-chloro-6-fluorobenzyl)oxy)phenyl)-3-((3,4-dichlorophenyl)amino)prop-2-en-1-one (CAS 478039-84-8)
- 5-O-Trityl-2,3'-anhydrothymidine (CAS 25442-42-6)
- Hexapeptide-10 (CAS 146439-94-3)
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