Paliperidone Impurity 58 CAS CATO-C4X-172458
| CAS No. | CATO-C4X-172458 |
| Molecular Formula | C12H14F2N2O |
| Molecular Weight | 240.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Paliperidone Impurity 58 (CAS CATO-C4X-172458, C12H14F2N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Paliperidone Impurity 58 (C12H14F2N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H14F2N2O |
| Molecular Weight | 240.25 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Paliperidone Standards
- Paliperidone Impurity 56 (CAS CATO-C4X-172456)
- Paliperidone Impurity 7 (CAS CATO-C4X-17247)
- Paliperidone Impurity 78 (CAS 691007-05-3)
- Paliperidone Impurity 81 (CAS 691007-07-5)
- Paliperidone Impurity 61 (CAS 1138463-56-5)
- Paliperidone Impurity 50 (CAS 260273-82-3)
- Paliperidone Impurity 103 (CAS CATO-C4X-1724103)
- Paliperidone Impurity 104 (CAS CATO-C4X-1724104)
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