Trazodone impurity 49 CAS CATO-C4X-177249
| CAS No. | CATO-C4X-177249 |
| Molecular Formula | C14H21Cl2N3 |
| Molecular Weight | 302.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Trazodone impurity 49 (C14H21Cl2N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 302.24 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Trazodone impurity 49 (CAS CATO-C4X-177249, C14H21Cl2N3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H21Cl2N3 |
| Molecular Weight | 302.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Trazodone Standards
- Trazodone Impurity 30 (CAS 79975-63-6)
- Trazodone Impurity 100 (CAS CATO-C4X-1772100)
- Trazodone Impurity 3 (CAS CATO-C4X-17723)
- Trazodone EP Impurity G (CAS 2470436-00-9)
- Trazodone Impurity 107 (CAS CATO-C4X-1772107)
- Trazodone impurity 40 (CAS 328410-01-1)
- Trazodone impurity 52 (CAS CATO-C4X-177252)
- Trazodone impurity 77 (CAS 1799917-53-5)
Recommended Standards
- Afatinib Impurity 52 (CAS CATO-C4X-100652)
- Olsalazine EP Impurity B (CAS 752188-68-4)
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- Abemaciclib Impurity 157 (CAS CATO-C4X-2937157)
- Cefotiam Impurity 48 (CAS CATO-C4X-120448)
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