Trazodone impurity 40 CAS 328410-01-1
| CAS No. | 328410-01-1 |
| Molecular Formula | C13H18BrClN2 |
| Molecular Weight | 317.65 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trazodone impurity 40.
As a process- or degradation-related impurity, Trazodone impurity 40 (CAS 328410-01-1, C13H18BrClN2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution, Trazodone impurity 40 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 317.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H18BrClN2 |
| Molecular Weight | 317.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Trazodone Standards
- Trazodone Impurity 107 (CAS CATO-C4X-1772107)
- Trazodone impurity 52 (CAS CATO-C4X-177252)
- Trazodone Impurity 34 (CAS CATO-C4X-177234)
- Trazodone EP Impurity G (CAS 2470436-00-9)
- Trazodone Impurity 3 (CAS CATO-C4X-17723)
- Trazodone Impurity 30 (CAS 79975-63-6)
- Trazodone impurity 49 (CAS CATO-C4X-177249)
- Trazodone impurity 50 (CAS 355396-54-2)
Recommended Standards
- Sitafloxacin Impurity N14 (CAS 127199-27-3)
- 3-{[3-Chloro-5-(trifluoromethyl)-pyridin-2-yl]oxy}benzoic acid 77529-22-7 (CAS 77529-22-7)
- Ethyl 7-chloro-6-(difluoromethoxy)-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 115700-25-9)
- 3-(Bromomethyl)-2-(4-chlorophenyl)-5-propyltetrahydrofuran (CAS 89058-36-6)
- Febuxostat Impurity 35 (CAS 34133-58-9)
- Cariodopa Isomer Impurity (Trifluoroacetate) (CAS 28875-92-5（free base）)
- Celecoxib Impurity 68 (CAS 170569-91-2)
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