Afatinib Impurity 52 CAS CATO-C4X-100652
| CAS No. | CATO-C4X-100652 |
| Molecular Formula | C14H8F2N4O2 |
| Molecular Weight | 302.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Afatinib Impurity 52 (CAS CATO-C4X-100652) is a certified pharmaceutical impurity reference standard with the molecular formula C14H8F2N4O2 and a molecular weight of 302.24 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Afatinib Impurity 52 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 302.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Afatinib Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H8F2N4O2 |
| Molecular Weight | 302.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Afatinib Standards
- Afatinib Impurity 46 (CAS 1449430-53-8)
- Afatinib Impurity 92 (CAS 2226537-61-5)
- Afatinib Impurity 76 (CAS CATO-C4X-100676)
- Afatinib Impurity 81 (CAS CATO-C4X-100681)
- Afatinib Impurity 83 (CAS CATO-C4X-100683)
- Afatinib Impurity 53 (CAS 1449430-45-8)
- Afatinib Impurity 22 (CAS 162012-67-1)
- Afatinib Impurity 51 (CAS CATO-C4X-100651)
Recommended Standards
- 92519-95-4 4H-1-Benzopyran-4-one, 2-(2,6-dihydroxyphenyl)-3,5,7-trihydroxy- 2-(2,6-Dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one Viscidulin I (CAS 92519-95-4)
- Trazodone impurity 49 (CAS CATO-C4X-177249)
- Pht-Gly-OSu (CAS 3397-29-3)
- Olsalazine EP Impurity B (CAS 752188-68-4)
- Relmapirazin impurity 11 (CAS CATO-C4X-333411)
- Levonorgestrel EP Impurity L (CAS 21800-83-9)
- Crisaborole impurity 160 (CAS CATO-C4X-2021160)
- (4-Chloro-phenyl)-[5-(3-chloro-5-trifluoromethyl-pyridin-2-yl)-pyrazol-1-yl]-methanone (CAS 1311278-51-9)
- N-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenyl)pivalamide (CAS 2390149-57-0)
- 2-(3-(Cyclohexylmethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2096333-64-9)
- N-(Pyridin-3-yl)pyrazin-2-amine (CAS 1028223-88-2)
- n-Methyl-1-(quinolin-2-yl)methanamine (CAS 136727-11-2)
- methyl 3-aminobenzo[d]isoxazole-6-carboxylate (CAS 501904-27-4)
- Semaglutide Impurity 188 (CAS CATO-C4X-2226188)
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