Verapamil Impurity 52 CAS CATO-C4X-177852
| CAS No. | CATO-C4X-177852 |
| Molecular Formula | C13H19NO3 |
| Molecular Weight | 237.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Verapamil Impurity 52.
Verapamil Impurity 52 (CAS CATO-C4X-177852) is a certified pharmaceutical impurity reference standard with the molecular formula C13H19NO3 and a molecular weight of 237.29 g/mol.
The molecular framework of Verapamil Impurity 52 (C13H19NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Verapamil Impurity 52 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H19NO3 |
| Molecular Weight | 237.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 1 |
Related Verapamil Standards
- Verapamil Impurity 49 (CAS CATO-C4X-177849)
- Verapamil Impurity 51 (CAS CATO-C4X-177851)
- Verapamil EP Impurity K (CAS 20850-49-1)
- Verapamil Impurity 19 (CAS CATO-C4X-177819)
- Verapamil EP Impurity C (CAS 3490-05-9)
- Verapamil EP Impurity L (CAS 14046-55-0)
- Verapamil Impurity 17 (CAS CATO-C4X-177817)
- Verapamil EP Impurity D (CAS 36770-74-8)
Recommended Standards
- Atenolol Impurity 25 (CAS CATO-C4X-154925)
- Tetracaine Impurity 21 (CAS CATO-C4X-192321)
- Bisoprolol EP Impurity L(Metoprolol EP Impurity C) (CAS 29122-74-5)
- Proparacaine Impurity 20 (CAS 1216179-28-0)
- Praziquantel EP Impurity C (CAS 125273-88-3)
- Upadacitinib Impurity 51 (CAS 2270173-65-2)
- Peramivir Impurity 76 (CAS CATO-C4X-183376)
- 4-(Trifluoromethoxy)indoline-2,3-dione (CAS 959236-54-5)
- 1-(1,3-Dioxolan-2-yl)propan-2-one (CAS 767-04-4)
- 5-(3-Chlorophenyl)-3-(p-tolyl)isoxazole (CAS 76112-08-8)
- 2,5-Dimethyl-3-phenylbenzofuran (CAS 69740-66-5)
- 2-Sulfanylpyridin-3-ol (CAS 23003-22-7)
- 2-Bromo-4-ethylanisole (CAS 99179-98-3)
- Semaglutide impurity 93 (CAS CATO-C4X-222693)
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