Verapamil EP Impurity D CAS 36770-74-8
| CAS No. | 36770-74-8 |
| Molecular Formula | C14H22ClNO2 |
| Molecular Weight | 271.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Verapamil EP Impurity D.
As a process- or degradation-related impurity, Verapamil EP Impurity D (CAS 36770-74-8, C14H22ClNO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Verapamil EP Impurity D (C14H22ClNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 271.78 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Verapamil EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H22ClNO2 |
| Molecular Weight | 271.78 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Verapamil Standards
- Verapamil Impurity N1 (CAS 102201-30-9)
- Verapamil Impurity 17 (CAS CATO-C4X-177817)
- Verapamil Impurity 20 (CAS 27339-25-9)
- Verapamil Impurity 33 (CAS 27487-66-7)
- Verapamil Impurity 19 (CAS CATO-C4X-177819)
- Verapamil Impurity 51 (CAS CATO-C4X-177851)
- Verapamil EP Impurity F (CAS 34245-14-2)
- Verapamil Impurity 52 (CAS CATO-C4X-177852)
Recommended Standards
- Sertraline EP Impurity D (1S, 4S-Isomer) (CAS 871838-58-3)
- Bupranolol (CAS 14556-46-8)
- Sertraline Impurity 45 (CAS CATO-C4X-134445)
- n-(1-(5-Chlorothiophen-2-yl)ethyl)thiophene-2-carboxamide (CAS 1209448-59-8)
- Tropicamide EP Impurity B (CAS 57322-50-6)
- Daclatasvir impurity 38 (CAS CATO-C4X-184838)
- Clopidogrel Impurity 103 (CAS CATO-C4X-1029103)
- 1-(2-Bromophenyl)propan-2-ol (CAS 210408-48-3)
- 1-Phenyl-2-(propan-2-ylsulfanyl)ethan-1-one (CAS 66502-11-2)
- 2-[[(2,4-dichlorophenyl)thio]methyl]-oxirane (CAS 122451-09-6)
- 9-Chloro-7-methoxy-1,2,3,4-tetrahydroacridine (CAS 53618-65-8)
- 5-Cyclopropoxy-2-(methylsulfonamido)isonicotinic acid (CAS 1243325-08-7)
- Dexamethasone Acetate EP Impurity C (CAS CATO-C4X-116540)
- Semaglutide Impurity 21(HO-Ste-L-γGlu-AEEA-AEEA-OH) (CAS 1335440-44-2)
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