Verapamil EP Impurity C CAS 3490-05-9
| CAS No. | 3490-05-9 |
| Molecular Formula | C12H19NO2 |
| Molecular Weight | 209.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Verapamil EP Impurity C is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Verapamil EP Impurity C (CAS 3490-05-9, C12H19NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H19NO2, Verapamil EP Impurity C contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 209.28 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19NO2 |
| Molecular Weight | 209.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Verapamil Standards
- Verapamil EP Impurity L (CAS 14046-55-0)
- Verapamil EP Impurity K (CAS 20850-49-1)
- Verapamil EP Impurity B (CAS 3490-06-0)
- Verapamil Impurity 25 (CAS 3893-01-4)
- Verapamil Impurity 27 (CAS 7306-46-9)
- Verapamil Impurity 49 (CAS CATO-C4X-177849)
- Verapamil Impurity 52 (CAS CATO-C4X-177852)
- Verapamil Impurity 24 (CAS 18086-24-3)
Recommended Standards
- Nicardipine Impurity 36 (CAS 115972-93-5)
- Olodaterol Impurity 22 (CAS CATO-C4X-194322)
- Naproxen Impurity 6 (CAS 174172-95-3)
- Tapentadol Impurity 14 (CAS CATO-C4X-209914)
- Lodoxamide lmpurity 14 (CAS 67451-25-6)
- Fosaprepitant Impurity 4 Dimeglumine (CAS 1523569-87-0)
- Difelikefalin Impurity 90 (CAS CATO-C4X-304190)
- 2-Methoxy-7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)naphthalen-1-amine (CAS 2756525-50-3)
- 1-(1H-Indol-1-yl)propan-2-amine (CAS 1227465-67-9)
- [6-(Difluoromethyl)-3-methoxypyridazin-4-yl]methanol (CAS 1591829-26-3)
- 62656-85-3 L-(2-~13~C)Alanine DTXSID80583881 (CAS 62656-85-3)
- Ethyl (2-chloropyrimidin-4-yl)glycinate (CAS 1251101-18-4)
- 5-Ethoxy-1-methyl-1H-pyrazole-4-carboxylic acid (CAS 1365939-36-1)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
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