Tenofovir alafenamide Impurity 54 CAS CATO-C4X-179754
| CAS No. | CATO-C4X-179754 |
| Molecular Formula | 2*C21H29N6O5P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 476.47 g/mol gives Tenofovir alafenamide Impurity 54 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Tenofovir alafenamide Impurity 54 (CAS CATO-C4X-179754), a pharmacopoeial impurity reference standard (molecular formula C21H29N6O5P, MW 476.47 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Tenofovir alafenamide Impurity 54 (C21H29N6O5P) is characterized by a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Tenofovir alafenamide Impurity 54 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | 2*C21H29N6O5P |
| Molecular Weight | 476.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 6 |
Related Tenofovir Standards
- Tenofovir alafenamide Impurity 79 (CAS 102-10-3)
- rac Tenofovir-d6 (CAS 1020719-94-1)
- Tenofovir disoproxil Impurity 142 (CAS 102537-97-3)
- Tenofovir Disoproxil Dimer (CAS 1093279-76-5)
- Tenofovir disoproxil Impurity 6 (CAS 1093279-77-6)
- Tenofovir disoproxil Impurity 28 (CAS 1115-59-9)
- Tenofovir Impurity 59 (CAS 116384-56-6)
- Tenofovir alafenamide impurity 85 (CAS 121149-98-2)
Recommended Standards
- Nebivolol Impurity 40 (CAS CATO-C4X-196840)
- Clopidogrel Impurity 53 HCl (CAS 1346231-35-3(free base))
- Abemaciclib Impurity 138 (CAS CATO-C4X-2937138)
- 4-Bromo-2-methylpyrido[4,3-d]pyrimidine (CAS 72668-53-2)
- Diethyl 3,4-dimethylthieno[2,3-b]thiophene-2,5-dicarboxylate (CAS 152487-69-9)
- 4-Fluorophenylglyoxal Hydrate (CAS 7468-86-2)
- 2-(3-Aminopyrrolidin-1-yl)-6,7-dihydro-3H-cyclopenta[d]pyrimidin-4(5H)-one (CAS 1240674-03-6)
- 5-bromo-2-(difluoromethyl)-1,3-thiazole (CAS 1319255-36-1)
- 2-[3-(Trifluoromethyl)phenoxy]acetohydrazide (CAS 307557-56-8)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
Why CATO?
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