Nintedanib Impurity 135 CAS CATO-C4X-1814135
| CAS No. | CATO-C4X-1814135 |
| Molecular Formula | C10H12Cl2O3 |
| Molecular Weight | 251.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Nintedanib Impurity 135 (CAS CATO-C4X-1814135) is a certified pharmaceutical impurity reference standard with the molecular formula C10H12Cl2O3 and a molecular weight of 251.11 g/mol.
Based on its molecular formula C10H12Cl2O3, Nintedanib Impurity 135 contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 251.11 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12Cl2O3 |
| Molecular Weight | 251.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 137 (CAS CATO-C4X-1814137)
- Nintedanib Impurity 138 (CAS CATO-C4X-1814138)
- Nintedanib Impurity 139 (CAS CATO-C4X-1814139)
- Nintedanib Impurity 141 (CAS CATO-C4X-1814141)
- Nintedanib Impurity 142 (CAS CATO-C4X-1814142)
- Nintedanib Impurity 31 (CAS 2514952-69-1)
- Nintedanib Impurity 11 (CAS CATO-C4X-181411)
- Nintedanib Impurity 25 (CAS 262368-25-2)
Recommended Standards
- 1,2-Bis(4-chlorophenyl)diazene (CAS 1602-00-2)
- 89976-15-8 7-iodo-1H-indole DTXSID00453092 (CAS 89976-15-8)
- Phenacetin Impurity 16 (CAS 30926-04-6)
- Phenacetin Impurity N1 (CAS 21650-51-1)
- Isoprenaline Impurity 18 (CAS CATO-C4X-277518)
- Mirogabalin Impurity 132 (CAS CATO-C4X-2924132)
- Oclacitinib Impurity 43 (CAS CATO-C4X-301843)
- 3-Methyl-8-nitro-2,3,6,7-tetrahydro-1h-purine-2,6-dione (CAS 93703-23-2)
- N-(3-(2-Methylthiazol-4-yl)phenyl)thiophene-2-sulfonamide (CAS 870984-34-2)
- 4-(1-Methyl-1H-indol-3-yl)butanoic acid (CAS 16244-09-0)
- 3-(4-Fluorobenzenesulfonyl)-2-methylpropanoic acid (CAS 1018300-28-1)
- 5-Amino-6-hydroxy-7-azaindole (CAS 1260385-20-3)
- 3-Chloro-6-(4-isopropylpiperazin-1-yl)pyridazine (CAS 919497-02-2)
- Tau Peptide (306-336) (Repeat 3 Domain) trifluoroacetate salt (CAS 330456-26-3)
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