Nintedanib Impurity 142 CAS CATO-C4X-1814142
| CAS No. | CATO-C4X-1814142 |
| Molecular Formula | C10H12Cl2O3 |
| Molecular Weight | 251.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Nintedanib Impurity 142 (CAS CATO-C4X-1814142, C10H12Cl2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Nintedanib Impurity 142 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 251.11 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H12Cl2O3 |
| Molecular Weight | 251.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
Related Nintedanib Standards
- Nintedanib Impurity 135 (CAS CATO-C4X-1814135)
- Nintedanib Impurity 137 (CAS CATO-C4X-1814137)
- Nintedanib Impurity 138 (CAS CATO-C4X-1814138)
- Nintedanib Impurity 139 (CAS CATO-C4X-1814139)
- Nintedanib Impurity 141 (CAS CATO-C4X-1814141)
- Nintedanib Impurity 31 (CAS 2514952-69-1)
- Nintedanib Impurity 11 (CAS CATO-C4X-181411)
- Nintedanib Impurity 25 (CAS 262368-25-2)
Recommended Standards
- 2,4′-Dichlorobenzophenone (CAS 85-29-0)
- 4,4＇-Dichlorobenzophenone (CAS 90-98-2)
- (S)-2-Bromo-1-(naphthalen-2-yl)ethan-1-ol (CAS 100306-23-8)
- 5-(Bromomethyl)-3-methyl-1-phenyl-1H-pyrazole (CAS 1020724-91-7)
- Gadodiamide Impurity 4 (CAS CATO-C4X-31434)
- Empagliflozin Impurity 73 (CAS CATO-C4X-106573)
- Pemafibrate Impurity 69 (CAS CATO-C4X-290369)
- 2-(4-Cyclopropyl-3-oxopiperazin-1-yl)acetic acid (CAS 1060807-83-1)
- Loxoprofen Impurity 49 (CAS 825-25-2)
- 1-(2-Methylbutyl)cyclopropane-1-carboxylic acid (CAS 1468591-14-1)
- Trimethyl((1-methylcyclopropyl)ethynyl)silane (CAS 158362-52-8)
- 4-Bromo-3-fluoroacetophenone, 97% (CAS 304445-49-6)
- 1-(Bromomethyl)-4-chloro-2-fluoro-5-methoxybenzene (CAS 374780-16-2)
- Semaglutide impurity 261 (CAS CATO-C4X-2226261)
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