Nintedanib Impurity 65 CAS 757218-01-2
| CAS No. | 757218-01-2 |
| Molecular Formula | C10H9Cl2NO3 |
| Molecular Weight | 262.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 262.09 g/mol gives Nintedanib Impurity 65 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Nintedanib Impurity 65 (CAS 757218-01-2, C10H9Cl2NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Nintedanib Impurity 65 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 262.09 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Nintedanib Impurity 65 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H9Cl2NO3 |
| Molecular Weight | 262.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Nintedanib Standards
- Nintedanib Impurity 22 (CAS 262368-30-9)
- Nintedanib Impurity 61 (CAS 2117628-65-4)
- Nintedanib Impurity 92 (CAS CATO-C4X-181492)
- Nintedanib Impurity 40 (CAS 78466-25-8)
- Nintedanib impurity 181 (CAS CATO-C4X-1814181)
- Nintedanib Impurity 15 (CAS 1160293-25-3)
- Nintedanib Impurity 90 (CAS CATO-C4X-181490)
- Nintedanib Impurity 135 (CAS CATO-C4X-1814135)
Recommended Standards
- Lamotrigine-13C3,d3, Major (CAS 1246815-13-3)
- Resmetirom impurity 74 (CAS 116688-45-0)
- Ziprasidone impurity 48 (CAS CATO-C4X-124048)
- 5-Bromo-6-methoxy-1-naphthonitrile (CAS 103604-47-3)
- Lapatinib Impurity 26 (CAS CATO-C4X-119126)
- Azilsartan Impurity 50 (CAS 1417576-02-3)
- Isepamicin Impurity 1 (CAS 118953-87-0)
- 4-O-Α-D-galactopyranuronosyl-α-D-galactopyranuronic acid (CAS 28144-27-6)
- 4-Chloro-5-(4-iodophenyl)-7h-pyrrolo[2,3-d]pyrimidin-2-amine (CAS 1204298-64-5)
- 5-Bromo-1-chloro-2-fluoro-3-nitrobenzene (CAS 1435806-75-9)
- 2-(Isothiazol-3-yl)acetonitrile (CAS 14217-70-0)
- 4-Ethynyl-1H-imidazole-5-carboxamide (CAS 126004-16-8)
- 4-Chloro-N,N-dipropylbenzamide (CAS 2447-87-2)
- Semaglutide impurity 270 (CAS CATO-C4X-2226270)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com