Nitrendipine Impurity 4 CAS CATO-C4X-18344
| CAS No. | CATO-C4X-18344 |
| Molecular Formula | C18H18N2O5 |
| Molecular Weight | 342.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Nitrendipine Impurity 4.
As a process- or degradation-related impurity, Nitrendipine Impurity 4 (CAS CATO-C4X-18344, C18H18N2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C18H18N2O5, Nitrendipine Impurity 4 contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 342.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nitrendipine Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H18N2O5 |
| Molecular Weight | 342.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Nitrogen Atoms | 2 |
Related Nitrendipine Standards
- Nitrendipine impurity 21 (CAS 1195583-65-3)
- Nitrendipine Impurity 3 (CAS 76258-20-3)
- Nitrendipine Impurity 7 (CAS 89267-42-5)
- Nitrendipine Impurity 5 (CAS 74936-73-5)
- Nitrendipine EP Impurity A (CAS 89267-41-4)
- Nitrendipine Impurity 2 (CAS CATO-C4X-18342)
- (+)-Nitrendipine (CAS 80890-07-9)
- Nitrendipine (CAS 39562-70-4)
Recommended Standards
- Indobufen Impurity 93 (CAS CATO-C4X-179293)
- Triphenyl phosphorothioate (CAS 597-82-0)
- Naphazoline impurity 13 (CAS CATO-C4X-144013)
- 5-Bromo-3-chloro-2-iodobenzonitrile (CAS 1000577-40-1)
- Dotinurad Impurity 91 (CAS CATO-C4X-249491)
- Ezetimibe Impurity 60 (CAS 1050631-82-7)
- Baloxavir Marboxil Impurity 155 (CAS CATO-C4X-2108155)
- Dipropylene Glycol Diacrylate (stabilized with MEHQ) (CAS 57472-68-1)
- (5-Bromo-2-methoxyphenyl)(2-methylphenyl)methanone (CAS 1097000-32-2)
- 5-Nitro-2-(5-(4-nitrophenyl)furan-2-yl)-1H-benzo[d]imidazole (CAS 41975-76-2)
- Ethyl 2-((2,4-dimethoxyphenyl)amino)-2-oxoacetate (CAS 24451-12-5)
- N-Boc 4-bromo-3,5-dimethylaniline (CAS 361436-27-3)
- Spiro[2.5]octan-6-amine hydrochloride (CAS 1256256-54-8)
- Glucagon-like peptide 2 (CAS 89750-15-2)
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