Hydroxychloroquine EP Impurity A CAS 1449223-88-4
| CAS No. | 1449223-88-4 |
| Molecular Formula | C18H26ClN3O2 |
| Molecular Weight | 351.87 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Hydroxychloroquine EP Impurity A (CAS 1449223-88-4), a pharmacopoeial impurity reference standard (molecular formula C18H26ClN3O2, MW 351.87 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C18H26ClN3O2, Hydroxychloroquine EP Impurity A contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 351.87 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H26ClN3O2 |
| Molecular Weight | 351.87 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Hydroxychloroquine Standards
- Hydroxychloroquine impurity 81 (CAS CATO-C4X-183581)
- Hydroxychloroquine Impurity 91 (CAS CATO-C4X-183591)
- Hydroxychloroquine Impurity 89 (CAS CATO-C4X-183589)
- Hydroxychloroquine D5 (CAS 118-42-3(Unlabelled))
- Hydroxychloroquine Impurity 22 (CAS CATO-C4X-183522)
- Hydroxychloroquine impurity 64 (CAS CATO-C4X-183564)
- Hydroxychloroquine impurity 65 (CAS CATO-C4X-183565)
- Hydroxychloroquine Impurity 97 (CAS CATO-C4X-183597)
Recommended Standards
- 81863-61-8 2-{[(4-Chlorophenyl)sulfanyl]acetyl}-N-phenylhydrazine-1-carbothioamide DTXSID40375724 (CAS 81863-61-8)
- 7-Chloro-2-methyl-3-((4-(methylsulfonyl)phenyl)thio)indolizine (CAS 917760-86-2)
- 6-Chloro-5-fluoro-9-((2-(trimethylsilyl)ethoxy)methyl)-9H-pyrrolo[2,3-b:5,4-c']dipyridine (CAS 1312755-64-8)
- 4-(2-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamido)benzoic acid (CAS 4113-88-6)
- Adefovir Impurity 32 (CAS 18997-19-8)
- Bisoprolol Impurity 69 (CAS 81349-58-8)
- Upadacitinib Impurity 222 (CAS CATO-C4X-2405222)
- 6-Bromophthalazin-1(2H)-one, 97% (CAS 75884-70-7)
- Denaverine Impurity 1 (CAS 2594-45-8)
- tert-butyl N-(tert-butoxycarbonylamino)-N-[3-[2-(trifluoromethyl)phenyl]-1-bicyclo[1.1.1]pentanyl]carbamate (CAS 2149634-47-7)
- Rotigotine EP Impurity H (CAS 1148154-91-9)
- 1-(4-Bromophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid (CAS 187998-44-3)
- 2-((5-(((3-Chlorophenyl)amino)methyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide (CAS 1071368-84-7)
- [D-Phe22]Semaglutide (CAS CATO-C4X-2226222)
Why CATO?
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